WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45)
1_MTQQP 6_ LRGVT 11_ SLRFN 16_ QDQSC 21_ FCCAM 26_ ETGVR 31_ IYNVE 36_ PLMEK 41_ GHLDH 46_ EQVGS 51_ MGLVE 56_ MLHRS 61_ NLLAL 66_ VGGGS 71_ SPKFS 76_ EISVL 81_ IWDDA 86_ REGKD 91_ SKEKL 96_ VLEFT 101_ FTKPV 106_ LSVRM 111_ RHDKI 116_ VIVLK 121_ NRIYV 126_ YSFPD 131_ NPRKL 136_ FEFDT 141_ RDNPK 146_ GLCDL 151_ CPSLE 156_ KQLLV 161_ FPGHK 166_ CGSLQ 171_ LVDLA 176_ STKPG 181_ TSSAP 186_ FTINA 191_ HQSDI 196_ ACVSL 201_ NQPGT 206_ VVASA 211_ SQKGT 216_ LIRLF 221_ DTQSK 226_ EKLVE 231_ LRRGT 236_ DPATL 241_ YCINF 246_ SHDSS 251_ FLCAS 256_ SDKGT 261_ VHIFA 266_ LKDTR 271_ LNRRS 276_ ALARV 281_ GKVGP 286_ MIGQY 291_ VDSQW 296_ SLASF 301_ TVPAE 306_ SACIC 311_ AFGRN 316_ TSKNV 321_ NSVIA 326_ ICVDG 331_ TFHKY 336_ VFTPD 341_ GNCNR 346_ EAFDV 351_YLDIC
1: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066)