V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)
1_MGSLF 6_ RSETM 11_ CLAQL 16_ FLQSG 21_ TAYEC 26_ LSALG 31_ EKGLV 36_ QFRDL 41_ NQNVS 46_ SFQRK 51_ FVGEV 56_ KRCEE 61_ LERIL 66_ VYLVQ 71_ EINRA 76_ DIPLP 81_ EGEAS 86_ PPAPP 91_ LKQVL 96_ EMQEQ 101_ LQKLE 106_ VELRE 111_ VTKNK 116_ EKLRK 121_ NLLEL 126_ IEYTH 131_ MLRVT 136_ KTFVK 141_ RNVEF 146_ EPTYE 151_ EFPSL 156_ ESDSL 161_ LDYSC 166_ MQRLG 171_ AKLGF 176_ VSGLI 181_ NQGKV 186_ EAFEK 191_ MLWRV 196_ CKGYT 201_ IVSYA 206_ ELDES 211_ LEDPE 216_ TGEVI 221_ KWYVF 226_ LISFW 231_ GEQIG 236_ HKVKK 241_ ICDCY 246_ HCHVY 251_ PYPNT 256_ AEERR 261_ EIQEG 266_ LNTRI 271_ QDLYT 276_ VLHKT 281_ EDYLR 286_ QVLCK 291_ AAESV 296_ YSRVI 301_ QVKKM 306_ KAIYH 311_ MLNMC 316_ SFDVT 321_ NKCLI 326_ AEVWC 331_ PEADL 336_ QDLRR 341_ ALEEG 346_ SRESG 351_ ATIPS 356_ FMNII 361_ PTKET 366_ PPTRI 371_ RTNKF 376_ TEGFQ 381_ NIVDA 386_ YGVGS 391_ YREVN 396_ PALFT 401_ IITFP 406_ FLFAV 411_ MFGDF 416_ GHGFV 421_ MFLFA 426_ LLLVL 431_ NENHP 436_ RLNQS 441_ QEIMR 446_ MFFNG 451_ RYILL 456_ LMGLF 461_ SVYTG 466_ LIYND 471_ CFSKS 476_ VNLFG 481_ SGWNV 486_ SAMYS 491_ SSHPP 496_ AEHKK 501_ MVLWN 506_ DSVVR 511_ HNSIL 516_ QLDPS 521_ IPGVF 526_ RGPYP 531_ LGIDP 536_ IWNLA 541_ TNRLT 546_ FLNSF 551_ KMKMS 556_ VILGI 561_ IHMTF 566_ GVILG 571_ IFNHL 576_ HFRKK 581_ FNIYL 586_ VSIPE 591_ LLFML 596_ CIFGY 601_ LIFMI 606_ FYKWL 611_ VFSAE 616_ TSRVA 621_ PSILI 626_ EFINM 631_ FLFPA 636_ SKTSG 641_ LYTGQ 646_ EYVQR 651_ VLLVV 656_ TALSV 661_ PVLFL 666_ GKPLF 671_ LLWLH 676_ NGRSC 681_ FGVNR 686_ SGYTL 691_ IRKDS 696_ EEEVS 701_ LLGSQ 706_ DIEEG 711_ NHQVE 716_ DGCRE 721_ MACEE 726_ FNFGE 731_ ILMTQ 736_ VIHSI 741_ EYCLG 746_ CISNT 751_ ASYLR 756_ LWALS 761_ LAHAQ 766_ LSDVL 771_ WAMLM 776_ RVGLR 781_ VDTTY 786_ GVLLL 791_ LPVIA 796_ LFAVL 801_ TIFIL 806_ LIMEG 811_ LSAFL 816_ HAIRL 821_ HWVEF 826_ QNKFY 831_ VGAGT 836_ KFVPF 841_ SFSLL 846_ SSKFN 851_NDDSV
1: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (PubMed:18157129). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633)