Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A)
1_MVLTL 6_ GESWP 11_ VLVGR 16_ RFLSL 21_ SAADG 26_ SDGSH 31_ DSWDV 36_ ERVAE 41_ WPWLS 46_ GTIRA 51_ VSHTD 56_ VTKKD 61_ LKVCV 66_ EFDGE 71_ SWRKR 76_ RWIEV 81_ YSLLR 86_ RAFLV 91_ EHNLV 96_ LAERK 101_ SPEIS 106_ ERIVQ 111_ WPAIT 116_ YKPLL 121_ DKAGL 126_ GSITS 131_ VRFLG 136_ DQQRV 141_ FLSKD 146_ LLKPI 151_ QDVNS 156_ LRLSL 161_ TDNQI 166_ VSKEF 171_ QALIV 176_ KHLDE 181_ SHLLK 186_ GDKNL 191_ VGSEV 196_ KIYSL 201_ DPSTQ 206_ WFSAT 211_ VINGN 216_ PASKT 221_ LQVNC 226_ EEIPA 231_ LKIVD 236_ PSLIH 241_ VEVVH 246_ DNLVT 251_ CGNSA 256_ RIGAV 261_ KRKSS 266_ ENNGT 271_ LVSKQ 276_ AKSCS 281_ EASPS 286_ MCPVQ 291_ SVPTT 296_ VFKEI 301_ LLGCT 306_ AATPP 311_ SKDPR 316_ QQSTP 321_ QAANS 326_ PPNLG 331_ AKIPQ 336_ GCHKQ 341_ SLPEE 346_ ISSCL 351_ NTKSE 356_ ALRTK 361_ PDVCK 366_ AGLLS 371_ KSSQI 376_ GTGDL 381_ KILTE 386_ PKGSC 391_ TQPKT 396_ NTDQE 401_ NRLES 406_ VPQAL 411_ TGLPK 416_ ECLPT 421_ KASSK 426_ AELEI 431_ ANPPE 436_ LQKHL 441_ EHAPS 446_ PSDVS 451_ NAPEV 456_ KAGVN 461_ SDSPN 466_ NCSGK 471_ KVEPS 476_ ALACR 481_ SQNLK 486_ ESSVK 491_ VDNES 496_ CCSRS 501_ NNKIQ 506_ NAPSR 511_ KSVLT 516_ DPAKL 521_ KKLQQ 526_ SGEAF 531_ VQDDS 536_ CVNIV 541_ AQLPK 546_ CRECR 551_ LDSLR 556_ KDKEQ 561_ QKDSP 566_ VFCRF 571_ FHFRR 576_ LQFNK 581_ HGVLR 586_ VEGFL 591_ TPNKY 596_ DNEAI 601_ GLWLP 606_ LTKNV 611_ VGIDL 616_ DTAKY 621_ ILANI 626_ GDHFC 631_ QMVIS 636_ EKEAM 641_ STIEP 646_ HRQVA 651_ WKRAV 656_ KGVRE 661_ MCDVC 666_ DTTIF 671_ NLHWV 676_ CPRCG 681_ FGVCV 686_ DCYRM 691_ KRKNC 696_ QQGAA 701_ YKTFS 706_ WLKCV 711_ KSQIH 716_ EPENL 721_ MPTQI 726_ IPGKA 731_ LYDVG 736_ DIVHS 741_ VRAKW 746_ GIKAN 751_ CPCSN 756_ RQFKL 761_ FSKPA 766_ SKEDL 771_ KQTSL 776_ AGEKP 781_ TLGAV 786_ LQQNP 791_ SVLEP 796_ AAVGG 801_ EAASK 806_ PAGSM 811_ KPACP 816_ ASTSP 821_ LNWLA 826_ DLTSG 831_ NVNKE 836_ NKEKQ 841_ PTMPI 846_ LKNEI 851_ KCLPP 856_ LPPLS 861_ KSSTV 866_ LHTFN 871_ STILT 876_ PVSNN 881_ NSGFL 886_ RNLLN 891_ SSTGK 896_ TENGL 901_ KNTPK 906_ ILDDI 911_ FASLV 916_ QNKTT 921_ SDLSK 926_ RPQGL 931_ TIKPS 936_ ILGFD 941_ TPHYW 946_ LCDNR 951_ LLCLQ 956_ DPNNK 961_ SNWNV 966_ FRECW 971_ KQGQP 976_ VMVSG 981_ VHHKL 986_ NSELW 991_ KPESF 996_ RKEFG 1001_ EQEVD 1006_ LVNCR 1011_ TNEII 1016_ TGATV 1021_ GDFWD 1026_ GFEDV 1031_ PNRLK 1036_ NEKEP 1041_ MVLKL 1046_ KDWPP 1051_ GEDFR 1056_ DMMPS 1061_ RFDDL 1066_ MANIP 1071_ LPEYT 1076_ RRDGK 1081_ LNLAS 1086_ RLPNY 1091_ FVRPD 1096_ LGPKM 1101_ YNAYG 1106_ LITPE 1111_ DRKYG 1116_ TTNLH 1121_ LDVSD 1126_ AANVM 1131_ VYVGI 1136_ PKGQC 1141_ EQEEE 1146_ VLKTI 1151_ QDGDS 1156_ DELTI 1161_ KRFIE 1166_ GKEKP 1171_ GALWH 1176_ IYAAK 1181_ DTEKI 1186_ REFLK 1191_ KVSEE 1196_ QGQEN 1201_ PADHD 1206_ PIHDQ 1211_ SWYLD 1216_ RSLRK 1221_ RLHQE 1226_ YGVQG 1231_ WAIVQ 1236_ FLGDV 1241_ VFIPA 1246_ GAPHQ 1251_ VHNLY 1256_ SCIKV 1261_ AEDFV 1266_ SPEHV 1271_ KHCFW 1276_ LTQEF 1281_ RYLSQ 1286_ THTNH 1291_ EDKLQ 1296_ VKNVI 1301_ YHAVK 1306_ DAVAM 1311_ LKASE 1316_SSFGK
1: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1