Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha)
1_MPGIV 6_ VFRRR 11_ WSVGS 16_ DDLVL 21_ PAIFL 26_ FLLHT 31_ TWFVI 36_ LSVVL 41_ FGLVY 46_ NPHEA 51_ CSLNL 56_ VDHGR 61_ GYLGI 66_ LLSCM 71_ IAEMA 76_ IIWLS 81_ MRGGI 86_ LYTEP 91_ RDSMQ 96_ YVLYV 101_ RLAIL 106_ VIEFI 111_ YAIVG 116_ IVWLT 121_ QYYTS 126_ CNDLT 131_ AKNVT 136_ LGMVV 141_ CNWVV 146_ ILSVC 151_ ITVLC 156_ VFDPT 161_ GRTFV 166_ KLRAT 171_ KRRQR 176_ NLRTY 181_ NLRHR 186_ LEEGQ 191_ ATSWS 196_ RRLKV 201_ FLCCT 206_ RTKDS 211_ QSDAY 216_ SEIAY 221_ LFAEF 226_ FRDLD 231_ IVPSD 236_ IIAGL 241_ VLLRQ 246_ RQRAK 251_ RNAVL 256_ DEANN 261_ DILAF 266_ LSGMP 271_ VTRNT 276_ KYLDL 281_ KNSQE 286_ MLRYK 291_ EVCYY 296_ MLFAL 301_ AAYGW 306_ PMYLM 311_ RKPAC 316_ GLCQL 321_ ARSCS 326_ CCLCP 331_ ARPRF 336_ APGVT 341_ IEEDN 346_ CCGCN 351_ AIAIR 356_ RHFLD 361_ ENMTA 366_ VDIVY 371_ TSCHD 376_ AVYET 381_ PFYVA 386_ VDHDK 391_ KKVVI 396_ SIRGT 401_ LSPKD 406_ ALTDL 411_ TGDAE 416_ RLPVE 421_ GHHGT 426_ WLGHK 431_ GMVLS 436_ AEYIK 441_ KKLEQ 446_ EMVLS 451_ QAFGR 456_ DLGRG 461_ TKHYG 466_ LIVVG 471_ HSLGA 476_ GTAAI 481_ LSFLL 486_ RPQYP 491_ TLKCF 496_ AYSPP 501_ GGLLS 506_ EDAME 511_ YSKEF 516_ VTAVV 521_ LGKDL 526_ VPRIG 531_ LSQLE 536_ GFRRQ 541_ LLDVL 546_ QRSTK 551_ PKWRI 556_ IVGAT 561_ KCIPK 566_ SELPE 571_ EVEVT 576_ TLAST 581_ RLWTH 586_ PSDLT 591_ IALSA 596_ STPLY 601_ PPGRI 606_ IHVVH 611_ NHPAE 616_ QCCCC 621_ EQEEP 626_ TYFAI 631_ WGDNK 636_ AFNEV 641_ IISPA 646_ MLHEH 651_ LPYVV 656_ MEGLN 661_ KVLEN 666_ YNKGK 671_ TALLS 676_ AAKVM 681_ VSPTE 686_ VDLTP 691_ ELIFQ 696_ QQPLP 701_ TGPPM 706_ PTGLA 711_ LELPT 716_ ADHRN 721_ SSVRS 726_ KSQSE 731_ MSLEG 736_ FSEGR 741_ LLSPV 746_ VAAAA 751_ RQDPV 756_ ELLLL 761_ STQER 766_ LAAEL 771_ QARRA 776_ PLATM 781_ ESLSD 786_ TESLY 791_ SFDSR 796_ RSSGF 801_ RSIRG 806_ SPSLH 811_ AVLER 816_ DEGHL 821_ FYIDP 826_ AIPEE 831_ NPSLS 836_ SRTEL 841_ LAADS 846_ LSKHS 851_ QDTQP 856_ LEAAL 861_ GSGGV 866_ TPERP 871_ PSAAA 876_ NDEEE 881_ EVGGG 886_ GGGPA 891_ SRGEL 896_ ALHNG 901_ RLGDS 906_ PSPQV 911_ LEFAE 916_ FIDSL 921_ FNLDS 926_ KSSSF 931_ QDLYC 936_ MVVPE 941_ SPTSD 946_ YAEGP 951_ KSPSQ 956_ QEILL 961_ RAQFE 966_ PNLVP 971_ KPPRL 976_ FAGSA 981_ DPSSG 986_ ISLSP 991_ SFPLS 996_ SSGEL 1001_ MDLTP 1006_ TGLSS 1011_ QECLA 1016_ ADKIR 1021_ TSTPT 1026_ GHGAS 1031_ PAKQD 1036_ELVIS
1: Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:23502535, PubMed:26668358). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:23502535, PubMed:26668358). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity)