E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451)
1_MGDPG 6_ SEIIE 11_ SVPPA 16_ GPEAS 21_ ESTTD 26_ ENEDD 31_ IQFVS 36_ EGPLR 41_ PVLEY 46_ IDLVS 51_ SDDEE 56_ PSTSY 61_ TDENI 66_ KRKDH 71_ IDYQK 76_ DKVAL 81_ TLARL 86_ ARHVE 91_ VEKQQ 96_ KEEKN 101_ RAFRE 106_ KIDFQ 111_ HAHGL 116_ QELEF 121_ IRGHS 126_ DTEAA 131_ RLCVD 136_ QWLKM 141_ PGLKT 146_ GTINC 151_ GTKSS 156_ FRRGG 161_ HTWVS 166_ GKPIL 171_ CPIMH 176_ CNKEF 181_ DNGHL 186_ LLGHL 191_ KRFDH 196_ SPCDP 201_ TITLH 206_ GPFFS 211_ SFACV 216_ VCYKK 221_ FVTQQ 226_ QYRDH 231_ LFDKE 236_ ATDDG 241_ HNNNL 246_ LPQII 251_ QCFAC 256_ PNCFL 261_ LFSRK 266_ EECSK 271_ HMSGK 276_ NHFHQ 281_ SFKLG 286_ DNKGI 291_ AHPIS 296_ FPSFA 301_ KKLLI 306_ SLCKD 311_ VPFQV 316_ KCVAC 321_ HKTLR 326_ SHMEL 331_ TAHFR 336_ VHCRN 341_ AGPVA 346_ VAEKS 351_ ITQVA 356_ EKFIL 361_ RGYCP 366_ DCNQV 371_ FVDET 376_ STQNH 381_ KQNSG 386_ HKVRV 391_ INSVE 396_ ESVLL 401_ YCHSS 406_ EGNKD 411_ PSSDL 416_ HLLLD 421_ QSKFS 426_ SLKRT 431_ MSIKE 436_ SSSLE 441_ CIAIP 446_ KKKMN 451_ LKDKS 456_ HEGVA 461_ CVQKE 466_ KSVVK 471_ TWFCE 476_ CNQRF 481_ PSEDA 486_ VEKHV 491_ FSANT 496_ MGYKC 501_ VVCGK 506_ VCDDS 511_ GVIRL 516_ HMSRI 521_ HGGAH 526_ LNNFL 531_ FWCRT 536_ CKKEL 541_ TRKDT 546_ IMAHV 551_ TEFHN 556_ GHRYF 561_ YEMDE 566_ VEGET 571_ LPSSS 576_ TTLDN 581_ LTANK 586_ PSSAI 591_ TVIDH 596_ SPANS 601_ SPRGK 606_ WQCRI 611_ CEDMF 616_ DSQEY 621_ VKQHC 626_ MSLAS 631_ HKFHR 636_ YSCAH 641_ CRKPF 646_ HKIET 651_ LYRHC 656_ QDEHD 661_ NEIKI 666_ KYFCG 671_ LCDLI 676_ FNVEE 681_ AFLSH 686_ YEEHH 691_ SIDYV 696_ FVSEK 701_ TETSI 706_ KTEDD 711_ FPVIE 716_ TSNQL 721_ TCGCR 726_ ESYIC 731_ KVNRK 736_ EDYSR 741_ CLQIM 746_ LDKGK 751_ LWFRC 756_ SLCSA 761_ TAQNL 766_ TDMNT 771_ HIHQV 776_ HKEKS 781_ DEEEQ 786_ QYVIK 791_ CGTCT 796_ KAFHD 801_ PESAQ 806_ QHFHR 811_ KHCFL 816_ QKPSV 821_ AHFGS 826_ EKSNL 831_ YKFTA 836_ SASHT 841_ ERKLK 846_ QAINY 851_ SKSLD 856_ MEKGV 861_ ENDLS 866_ YQNIE 871_ EEIVE 876_ LPDLD 881_ YLRTM 886_ THIVF 891_ VDFDN 896_ WSNFF 901_ GHLPG 906_ HLNQG 911_ TFIWG 916_ FQGGN 921_ TNWKP 926_ PLNCK 931_ IYNYL 936_ NRIGC 941_ FFLHP 946_ RCSKR 951_ KDAAD 956_ FAICM 961_ HAGRL 966_ DEQLP 971_ KQIPF 976_ TILSG 981_ DQGFL 986_ ELENQ 991_ FKKTQ 996_ RPAHI 1001_ LNPHH 1006_ LEGDM 1011_ MCALL 1016_ NSISD 1021_ TTKEC 1026_ DSDDN 1031_ MGAKN 1036_ TSIGE 1041_ EFIST 1046_ EDVEL 1051_ EEAIR 1056_RSLEE
1: E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483)