Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)
1_MAEGG 6_ AADLD 11_ TQRSD 16_ IATLL 21_ KTSLR 26_ KGDTW 31_ YLVDS 36_ RWFKQ 41_ WKKYV 46_ GFDSW 51_ DKYQM 56_ GDQNV 61_ YPGPI 66_ DNSGL 71_ LKDGD 76_ AQSLK 81_ EHLID 86_ ELDYI 91_ LLPTE 96_ GWNKL 101_ VSWYT 106_ LMEGQ 111_ EPIAR 116_ KVVEQ 121_ GMFVK 126_ HCKVE 131_ VYLTE 136_ LKLCE 141_ NGNMN 146_ NVVTR 151_ RFSKA 156_ DTIDT 161_ IEKEI 166_ RKIFS 171_ IPDEK 176_ ETRLW 181_ NKYMS 186_ NTFEP 191_ LNKPD 196_ STIQD 201_ AGLYQ 206_ GQVLV 211_ IEQKN 216_ EDGTW 221_ PRGPS 226_ TPKSP 231_ GASNF 236_ STLPK 241_ ISPSS 246_ LSNNY 251_ NNMNN 256_ RNVKN 261_ SNYCL 266_ PSYTA 271_ YKNYD 276_ YSEPG 281_ RNNEQ 286_ PGLCG 291_ LSNLG 296_ NTCFM 301_ NSAIQ 306_ CLSNT 311_ PPLTE 316_ YFLND 321_ KYQEE 326_ LNFDN 331_ PLGMR 336_ GEIAK 341_ SYAEL 346_ IKQMW 351_ SGKFS 356_ YVTPR 361_ AFKTQ 366_ VGRFA 371_ PQFSG 376_ YQQQD 381_ CQELL 386_ AFLLD 391_ GLHED 396_ LNRIR 401_ KKPYI 406_ QLKDA 411_ DGRPD 416_ KVVAE 421_ EAWEN 426_ HLKRN 431_ DSIIV 436_ DIFHG 441_ LFKST 446_ LVCPE 451_ CAKIS 456_ VTFDP 461_ FCYLT 466_ LPLPM 471_ KKERT 476_ LEVYL 481_ VRMDP 486_ LTKPM 491_ QYKVV 496_ VPKIG 501_ NILDL 506_ CTALS 511_ ALSGI 516_ PADKM 521_ IVTDI 526_ YNHRF 531_ HRIFA 536_ MDENL 541_ SSIME 546_ RDDIY 551_ VFEIN 556_ INRTE 561_ DTEHV 566_ IIPVC 571_ LREKF 576_ RHSSY 581_ THHTG 586_ SSLFG 591_ QPFLM 596_ AVPRN 601_ NTEDK 606_ LYNLL 611_ LLRMC 616_ RYVKI 621_ STETE 626_ ETEGS 631_ LHCCK 636_ DQNIN 641_ GNGPN 646_ GIHEE 651_ GSPSE 656_ METDE 661_ PDDES 666_ SQDQE 671_ LPSEN 676_ ENSQS 681_ EDSVG 686_ GDNDS 691_ ENGLC 696_ TEDTC 701_ KGQLT 706_ GHKKR 711_ LFTFQ 716_ FNNLG 721_ NTDIN 726_ YIKDD 731_ TRHIR 736_ FDDRQ 741_ LRLDE 746_ RSFLA 751_ LDWDP 756_ DLKKR 761_ YFDEN 766_ AAEDF 771_ EKHES 776_ VEYKP 781_ PKKPF 786_ VKLKD 791_ CIELF 796_ TTKEK 801_ LGAED 806_ PWYCP 811_ NCKEH 816_ QQATK 821_ KLDLW 826_ SLPPV 831_ LVVHL 836_ KRFSY 841_ SRYMR 846_ DKLDT 851_ LVDFP 856_ INDLD 861_ MSEFL 866_ INPNA 871_ GPCRY 876_ NLIAV 881_ SNHYG 886_ GMGGG 891_ HYTAF 896_ AKNKD 901_ DGKWY 906_ YFDDS 911_ SVSTA 916_ SEDQI 921_ VSKAA 926_ YVLFY 931_ QRQDT 936_ FSGTG 941_ FFPLD 946_ RETKG 951_ ASAAT 956_ GIPLE 961_ SDEDS 966_ NDNDN 971_ DIENE 976_NCMHT
1: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24852371). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067)
2: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway