Rho family-interacting cell polarization regulator 2
1_MLVGS 6_ QSFSP 11_ GGPNG 16_ IIRSQ 21_ SFAGF 26_ SGLQE 31_ RRSRC 36_ NSFIE 41_ NSSAL 46_ KKPQA 51_ KLKKM 56_ HNLGH 61_ KNNNP 66_ PKEPQ 71_ PKRVE 76_ EVYRA 81_ LKNGL 86_ DEYLE 91_ VHQTE 96_ LDKLT 101_ AQLKD 106_ MKRNS 111_ RLGVL 116_ YDLDK 121_ QIKTI 126_ ERYMR 131_ RLEFH 136_ ISKVD 141_ ELYEA 146_ YCIQR 151_ RLQDG 156_ ASKMK 161_ QAFAT 166_ SPASK 171_ AARES 176_ LTEIN 181_ RSFKE 186_ YTENM 191_ CTIEV 196_ ELENL 201_ LGEFS 206_ IKMKG 211_ LAGFA 216_ RLCPG 221_ DQYEI 226_ FMKYG 231_ RQRWK 236_ LKGKI 241_ EVNGK 246_ QSWDG 251_ EETVF 256_ LPLIV 261_ GFISI 266_ KVTEL 271_ KGLAT 276_ HILVG 281_ SVTCE 286_ TKELF 291_ AARPQ 296_ VVAVD 301_ INDLG 306_ TIKLN 311_ LEITW 316_ YPFDV 321_ EDMTA 326_ SSGAG 331_ NKAAA 336_ LQRRM 341_ SMYSQ 346_ GTPET 351_ PTFKD 356_ HSFFR 361_ WLHPS 366_ PDKPR 371_ RLSVL 376_ SALQD 381_ TFFAK 386_ LHRSR 391_ SFSDL 396_ PSLRP 401_ SPKAV 406_ LELYS 411_ NLPDD 416_ IFENG 421_ KAAEE 426_ KMPLS 431_ LSFSD 436_ LPNGD 441_ CALTS 446_ HSTGS 451_ PSNST 456_ NPEIT 461_ ITPAE 466_ FNLSS 471_ LASQN 476_ EGMDD 481_ TSSAS 486_ SRNSL 491_ GEGQE 496_ PKSHL 501_ KEEDP 506_ EEPRK 511_ PASAP 516_ SEACR 521_ RQSSG 526_ AGAEH 531_ LFLEN 536_ DVAEA 541_ LLQES 546_ EEASE 551_ LKPVE 556_ LDTSE 561_ GNITK 566_ QLVKR 571_ LTSAE 576_ VPMAT 581_ DRLLS 586_ EGSVG 591_ GESEG 596_ CRSFL 601_ DGSLE 606_ DAFNG 611_ LLLAL 616_ EPHKE 621_ QYKEF 626_ QDLNQ 631_ EVMNL 636_ DDILK 641_ CKPAV 646_ SRSRS 651_ SSLSL 656_ TVESA 661_ LESFD 666_ FLNTS 671_ DFDEE 676_ EDGDE 681_ VCNVG 686_ GGADS 691_ VFSDT 696_ ETEKH 701_ SYRSV 706_ HPEAR 711_ GHLSE 716_ ALTED 721_ TGVGT 726_ SVAGS 731_ PLPLT 736_ TGNES 741_ LDITI 746_ VRHLQ 751_ YCTQL 756_ VQQIV 761_ FSSKT 766_ PFVAR 771_ SLLEK 776_ LSRQI 781_ QVMEK 786_ LAAVS 791_ DENIG 796_ NISSV 801_ VEAIP 806_ EFHKK 811_ LSLLS 816_ FWTKC 821_ CSPVG 826_ VYHSP 831_ ADRVM 836_ KQLEA 841_ SFART 846_ VNKEY 851_ PGLAD 856_ PVFRT 861_ LVSQI 866_ LDRAE 871_ PLLSS 876_ SLSSE 881_ VVTVF 886_ QYYSY 891_ FTSHG 896_ VSDLE 901_ SYLSQ 906_ LARQV 911_ SMVQT 916_ LQSLR 921_ DEKLL 926_ QTMSD 931_ LAPSN 936_ LLAQQ 941_ EVLRT 946_ LALLL 951_ TREDN 956_ EVSEA 961_ VTLYL 966_ AAASK 971_ NQHFR 976_ EKALL 981_ YYCEA 986_ LTKTN 991_ LQLQK 996_ AACLA 1001_ LKILE 1006_ ATESI 1011_ KMLVT 1016_ LCQSD 1021_ TEEIR 1026_ NVASE 1031_ TLLSL 1036_ GEDGR 1041_ LAYEQ 1046_ LDKFP 1051_ RDCVK 1056_ VGGRH 1061_GTEVA
1: Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:23241886, PubMed:24687993, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875)
2: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504)