Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162)
1_MLSVV 6_ ENGLD 11_ PQAAI 16_ PVIKK 21_ KLVGS 26_ VKALQ 31_ KQYVS 36_ LDTVV 41_ TSEDG 46_ DANTM 51_ CSALE 56_ AVFIH 61_ GLHAK 66_ HIRAE 71_ AGGKR 76_ KKSAH 81_ QKPLP 86_ QPVFW 91_ PLLKA 96_ VTHKH 101_ IISEL 106_ EHLTF 111_ VNTDV 116_ GRCRA 121_ WLRLA 126_ LNDGL 131_ MECYL 136_ KLLLQ 141_ EQARL 146_ HEYYQ 151_ PTALL 156_ RDAEE 161_ GEFLL 166_ SFLQG 171_ LTSLS 176_ FELSY 181_ KSAIL 186_ NEWTL 191_ TPLAL 196_ SGLCP 201_ LSELD 206_ PLSTS 211_ GAELQ 216_ RKESL 221_ DSISH 226_ SSGSE 231_ DIEVH 236_ HSGHK 241_ IRRNQ 246_ KLTAS 251_ SLSLD 256_ TASSS 261_ QLSCS 266_ LNSDS 271_ CLLQE 276_ NGSKS 281_ PDHCE 286_ EPMSC 291_ DSDLG 296_ TANAE 301_ DSDRS 306_ LQEVL 311_ LEFSK 316_ AQVNS 321_ VPTNG 326_ LSQET 331_ EIPTP 336_ QASLS 341_ LHGLN 346_ TSTYL 351_ HCEAP 356_ AEPLP 361_ AQAAS 366_ GTQDG 371_ VHVQE 376_ PRPQA 381_ PSPLD 386_ LQQPV 391_ ESTSG 396_ QQPSS 401_ TVSET 406_ AREVG 411_ QGNGL 416_ QKAQA 421_ HDGAG 426_ LKLVV 431_ SSPTS 436_ PKNKS 441_ WISED 446_ DFYRP 451_ SREQP 456_ LESAS 461_ DHPIA 466_ SYRGT 471_ PGSRP 476_ GLHRH 481_ FSQEP 486_ RKNCS 491_ LGALD 496_ QACVP 501_ SPGRR 506_ QAQAA 511_ PSQGH 516_ KSFRV 521_ VHRRQ 526_ MGLSN 531_ PFRGL 536_ MKLGT 541_ VERRG 546_ AMGIW 551_ KELFC 556_ ELSPL 561_ EFRLY 566_ LSNEE 571_ HTCVE 576_ NCSLL 581_ RCESV 586_ GPAHS 591_ DGRFE 596_ LVFSG 601_ KKLAL 606_ RASSQ 611_ DEAED 616_ WLDRV 621_ REALQ 626_ KVRPQ 631_ QEDEW 636_ VNVQY 641_ PDQPE 646_ EPPEA 651_ PQGCL 656_ SPSDL 661_ LSEPA 666_ ALQGT 671_ QFDWS 676_ SAQVP 681_ EPDAI 686_ KESLL 691_ YLYMD 696_ RTWMP 701_ YIFSL 706_ SLEAL 711_ KCFRI 716_ RNNEK 721_ MLSDS 726_ HGVET 731_ IRDIL 736_ PDTSL 741_ GGPSF 746_ FKIIT 751_ AKAVL 756_ KLQAG 761_ NAEEA 766_ ALWRD 771_ LVRKV 776_ LASYL 781_ ETAEE 786_ AVTLG 791_ GSLDE 796_ NCQEV 801_ LKFAT 806_ RENGF 811_ LLQYL 816_ VAIPM 821_ EKGLD 826_ SQGCF 831_ CAGCS 836_ RQIGF 841_ SFVRP 846_ KLCAF 851_ SGLYY 856_ CDICH 861_ QDDAS 866_ VIPAR 871_ IIHNW 876_ DLTKR 881_ PICRQ 886_ ALKFL 891_ TQIRA 896_ QPLIN 901_ LQMVN 906_ ASLYE 911_ HVERM 916_ HLIGR 921_ RREQL 926_ KLLGD 931_ YLGLC 936_ RSGAL 941_ KELSK 946_ RLNHR 951_ NYLLE 956_ SPHRF 961_ SVADL 966_ QQIAD 971_ GVYEG 976_ FLKAL 981_ IEFAS 986_ QHVYH 991_ CDLCT 996_ QRGFI 1001_ CQICQ 1006_ HHDII 1011_ FPFEF 1016_ DTTVR 1021_ CAECK 1026_ TVFHQ 1031_ SCQAV 1036_ VKKGC 1041_ PRCAR 1046_ RRKYQ 1051_EQNIF
1: Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity)
2: (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7