Insulin receptor substrate 2 (IRS-2)
1_MASPP 6_ RHGPP 11_ GPASG 16_ DGPNL 21_ NNNNN 26_ NNNHS 31_ VRKCG 36_ YLRKQ 41_ KHGHK 46_ RFFVL 51_ RGPGA 56_ GGDEA 61_ TAGGG 66_ SAPQP 71_ PRLEY 76_ YESEK 81_ KWRSK 86_ AGAPK 91_ RVIAL 96_ DCCLN 101_ INKRA 106_ DAKHK 111_ YLIAL 116_ YTKDE 121_ YFAVA 126_ AENEQ 131_ EQEGW 136_ YRALT 141_ DLVSE 146_ GRAAA 151_ GDAPP 156_ AAAPA 161_ ASCSA 166_ SLPGA 171_ LGGSA 176_ GAAGA 181_ EDSYG 186_ LVAPA 191_ TAAYR 196_ EVWQV 201_ NLKPK 206_ GLGQS 211_ KNLTG 216_ VYRLC 221_ LSART 226_ IGFVK 231_ LNCEQ 236_ PSVTL 241_ QLMNI 246_ RRCGH 251_ SDSFF 256_ FIEVG 261_ RSAVT 266_ GPGEL 271_ WMQAD 276_ DSVVA 281_ QNIHE 286_ TILEA 291_ MKALK 296_ ELFEF 301_ RPRSK 306_ SQSSG 311_ SSATH 316_ PISVP 321_ GARRH 326_ HHLVN 331_ LPPSQ 336_ TGLVR 341_ RSRTD 346_ SLAAT 351_ PPAAK 356_ CSSCR 361_ VRTAS 366_ EGDGG 371_ AAAGA 376_ AAAGA 381_ RPVSV 386_ AGSPL 391_ SPGPV 396_ RAPLS 401_ RSHTL 406_ SGGCG 411_ GRGSK 416_ VALLP 421_ AGGAL 426_ QHSRS 431_ MSMPV 436_ AHSPP 441_ AATSP 446_ GSLSS 451_ SSGHG 456_ SGSYP 461_ PPPGP 466_ HPPLP 471_ HPLHH 476_ GPGQR 481_ PSSGS 486_ ASASG 491_ SPSDP 496_ GFMSL 501_ DEYGS 506_ SPGDL 511_ RAFCS 516_ HRSNT 521_ PESIA 526_ ETPPA 531_ RDGGG 536_ GGEFY 541_ GYMTM 546_ DRPLS 551_ HCGRS 556_ YRRVS 561_ GDAAQ 566_ DLDRG 571_ LRKRT 576_ YSLTT 581_ PARQR 586_ PVPQP 591_ SSASL 596_ DEYTL 601_ MRATF 606_ SGSAG 611_ RLCPS 616_ CPASS 621_ PKVAY 626_ HPYPE 631_ DYGDI 636_ EIGSH 641_ RSSSS 646_ NLGAD 651_ DGYMP 656_ MTPGA 661_ ALAGS 666_ GSGSC 671_ RSDDY 676_ MPMSP 681_ ASVSA 686_ PKQIL 691_ QPRAA 696_ AAAAA 701_ AVPSA 706_ GPAGP 711_ APTSA 716_ AGRTF 721_ PASGG 726_ GYKAS 731_ SPAES 736_ SPEDS 741_ GYMRM 746_ WCGSK 751_ LSMEH 756_ ADGKL 761_ LPNGD 766_ YLNVS 771_ PSDAV 776_ TTGTP 781_ PDFFS 786_ AALHP 791_ GGEPL 796_ RGVPG 801_ CCYSS 806_ LPRSY 811_ KAPYT 816_ CGGDS 821_ DQYVL 826_ MSSPV 831_ GRILE 836_ EERLE 841_ PQATP 846_ GPSQA 851_ ASAFG 856_ AGPTQ 861_ PPHPV 866_ VPSPV 871_ RPSGG 876_ RPEGF 881_ LGQRG 886_ RAVRP 891_ TRLSL 896_ EGLPS 901_ LPSMH 906_ EYPLP 911_ PEPKS 916_ PGEYI 921_ NIDFG 926_ EPGAR 931_ LSPPA 936_ PPLLA 941_ SAASS 946_ SSLLS 951_ ASSPA 956_ SSLGS 961_ GTPGT 966_ SSDSR 971_ QRSPL 976_ SDYMN 981_ LDFSS 986_ PKSPK 991_ PGAPS 996_ GHPVG 1001_ SLDGL 1006_ LSPEA 1011_ SSPYP 1016_ PLPPR 1021_ PSASP 1026_ SSSLQ 1031_ PPPPP 1036_ PAPGE 1041_ LYRLP 1046_ PASAV 1051_ ATAQG 1056_ PGAAS 1061_ SLSSD 1066_ TGDNG 1071_ DYTEM 1076_ AFGVA 1081_ ATPPQ 1086_ PIAAP 1091_ PKPEA 1096_ ARVAS 1101_ PTSGV 1106_ KRLSL 1111_ MEQVS 1116_ GVEAF 1121_ LQASQ 1126_ PPDPH 1131_ RGAKV 1136_ IRADP 1141_ QGGRR 1146_ RHSSE 1151_ TFSST 1156_ TTVTP 1161_ VSPSF 1166_ AHNPK 1171_ RHNSA 1176_ SVENV 1181_ SLRKS 1186_ SEGGV 1191_ GVGPG 1196_ GGDEP 1201_ PTSPR 1206_ QLQPA 1211_ PPLAP 1216_ QGRPW 1221_ TPGQP 1226_ GGLVG 1231_ CPGSG 1236_ GSPMR 1241_ RETSA 1246_ GFQNG 1251_ LNYIA 1256_ IDVRE 1261_ EPGLP 1266_ PQPQP 1271_ PPPPL 1276_ PQPGD 1281_ KSSWG 1286_ RTRSL 1291_ GGLIS 1296_ AVGVG 1301_ STGGG 1306_ CGGPG 1311_ PGALP 1316_ PANTY 1321_ ASIDF 1326_ LSHHL 1331_KEATI
1: Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239)