TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
1_MSLLN 6_ CENSC 11_ GSSQS 16_ ESDCC 21_ VAMAS 26_ SCSAV 31_ TKDDS 36_ VGGTA 41_ STGNL 46_ SSSFM 51_ EEIQG 56_ YDVEF 61_ DPPLE 66_ SKYEC 71_ PICLM 76_ ALREA 81_ VQTPC 86_ GHRFC 91_ KACII 96_ KSIRD 101_ AGHKC 106_ PVDNE 111_ ILLEN 116_ QLFPD 121_ NFAKR 126_ EILSL 131_ MVKCP 136_ NEGCL 141_ HKMEL 146_ RHLED 151_ HQAHC 156_ EFALM 161_ DCPQC 166_ QRPFQ 171_ KFHIN 176_ IHILK 181_ DCPRR 186_ QVSCD 191_ NCAAS 196_ MAFED 201_ KEIHD 206_ QNCPL 211_ ANVIC 216_ EYCNT 221_ ILIRE 226_ QMPNH 231_ YDLDC 236_ PTAPI 241_ PCTFS 246_ TFGCH 251_ EKMQR 256_ NHLAR 261_ HLQEN 266_ TQSHM 271_ RMLAQ 276_ AVHSL 281_ SVIPD 286_ SGYIS 291_ EVRNF 296_ QETIH 301_ QLEGR 306_ LVRQD 311_ HQIRE 316_ LTAKM 321_ ETQSM 326_ YVSEL 331_ KRTIR 336_ TLEDK 341_ VAEIE 346_ AQQCN 351_ GIYIW 356_ KIGNF 361_ GMHLK 366_ CQEEE 371_ KPVVI 376_ HSPGF 381_ YTGKP 386_ GYKLC 391_ MRLHL 396_ QLPTA 401_ QRCAN 406_ YISLF 411_ VHTMQ 416_ GEYDS 421_ HLPWP 426_ FQGTI 431_ RLTIL 436_ DQSEA 441_ PVRQN 446_ HEEIM 451_ DAKPE 456_ LLAFQ 461_ RPTIP 466_ RNPKG 471_ FGYVT 476_ FMHLE 481_ ALRQR 486_ TFIKD 491_ DTLLV 496_ RCEVS 501_ TRFDM 506_ GSLRR 511_ EGFQP 516_RSTDA
1: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:11057907, PubMed:18347055, PubMed:19465916, PubMed:19713527, PubMed:27746020, PubMed:31620128). Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (PubMed:19675569). Leads to the activation of NF-kappa-B and JUN (PubMed:16378096, PubMed:17135271, PubMed:17703191). Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes (PubMed:18093978, PubMed:18758450). Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed:12140561, PubMed:19825828, PubMed:8837778). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (By similarity). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by initiating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: TRAF6 catalyzes initial 'Lys-63'-linked-polyubiquitin chains that are then branched via 'Lys-48'-linked polyubiquitin by HUWE1 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Participates also in the TCR signaling by ubiquitinating LAT (PubMed:23514740, PubMed:25907557)