Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170)
1_MADKV 6_ RRQRP 11_ RRRVC 16_ WALVA 21_ VLLAD 26_ LLALS 31_ DTLAV 36_ MSVDL 41_ GSESM 46_ KVAIV 51_ KPGVP 56_ MEIVL 61_ NKESR 66_ RKTPV 71_ IVTLK 76_ ENERF 81_ FGDSA 86_ ASMAI 91_ KNPKA 96_ TLRYF 101_ QHLLG 106_ KQADN 111_ PHVAL 116_ YQARF 121_ PEHEL 126_ TFDPQ 131_ RQTVH 136_ FQISS 141_ QLQFS 146_ PEEVL 151_ GMVLN 156_ YSRSL 161_ AEDFA 166_ EQPIK 171_ DAVIT 176_ VPVFF 181_ NQAER 186_ RAVLQ 191_ AARMA 196_ GLKVL 201_ QLIND 206_ NTATA 211_ LSYGV 216_ FRRKD 221_ INTTA 226_ QNIMF 231_ YDMGS 236_ GSTVC 241_ TIVTY 246_ QMVKT 251_ KEAGM 256_ QPQLQ 261_ IRGVG 266_ FDRTL 271_ GGLEM 276_ ELRLR 281_ ERLAG 286_ LFNEQ 291_ RKGQR 296_ AKDVR 301_ ENPRA 306_ MAKLL 311_ REANR 316_ LKTVL 321_ SANAD 326_ HMAQI 331_ EGLMD 336_ DVDFK 341_ AKVTR 346_ VEFEE 351_ LCADL 356_ FERVP 361_ GPVQQ 366_ ALQSA 371_ EMSLD 376_ EIEQV 381_ ILVGG 386_ ATRVP 391_ RVQEV 396_ LLKAV 401_ GKEEL 406_ GKNIN 411_ ADEAA 416_ AMGAV 421_ YQAAA 426_ LSKAF 431_ KVKPF 436_ VVRDA 441_ VVYPI 446_ LVEFT 451_ REVEE 456_ EPGIH 461_ SLKHN 466_ KRVLF 471_ SRMGP 476_ YPQRK 481_ VITFN 486_ RYSHD 491_ FNFHI 496_ NYGDL 501_ GFLGP 506_ EDLRV 511_ FGSQN 516_ LTTVK 521_ LKGVG 526_ DSFKK 531_ YPDYE 536_ SKGIK 541_ AHFNL 546_ DESGV 551_ LSLDR 556_ VESVF 561_ ETLVE 566_ DSAEE 571_ ESTLT 576_ KLGNT 581_ ISSLF 586_ GGGTT 591_ PDAKE 596_ NGTDT 601_ VQEEE 606_ ESPAE 611_ GSKDE 616_ PGEQV 621_ ELKEE 626_ AEAPV 631_ EDGSQ 636_ PPPPE 641_ PKGDA 646_ TPEGE 651_ KATEK 656_ ENGDK 661_ SEAQK 666_ PSEKA 671_ EAGPE 676_ GVAPA 681_ PEGEK 686_ KQKPA 691_ RKRRM 696_ VEEIG 701_ VELVV 706_ LDLPD 711_ LPEDK 716_ LAQSV 721_ QKLQD 726_ LTLRD 731_ LEKQE 736_ REKAA 741_ NSLEA 746_ FIFET 751_ QDKLY 756_ QPEYQ 761_ EVSTE 766_ EQREE 771_ ISGKL 776_ SAAST 781_ WLEDE 786_ GVGAT 791_ TVMLK 796_ EKLAE 801_ LRKLC 806_ QGLFF 811_ RVEER 816_ KKWPE 821_ RLSAL 826_ DNLLN 831_ HSSMF 836_ LKGAR 841_ LIPEM 846_ DQIFT 851_ EVEMT 856_ TLEKV 861_ INETW 866_ AWKNA 871_ TLAEQ 876_ AKLPA 881_ TEKPV 886_ LLSKD 891_ IEAKM 896_ MALDR 901_ EVQYL 906_ LNKAK 911_ FTKPR 916_ PRPKD 921_ KNGTR 926_ AEPPL 931_ NASAS 936_ DQGEK 941_ VIPPA 946_ GQTED 951_ AEPIS 956_ EPEKV 961_ ETGSE 966_ PGDTE 971_ PLELG 976_ GPGAE 981_ PEQKE 986_ QSTGQ 991_KRPLK
1: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding