E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364)
1_MAEAS 6_ AAGAD 11_ SGAAV 16_ AAHRF 21_ FCHFC 26_ KGEVS 31_ PKLPE 36_ YICPR 41_ CESGF 46_ IEEVT 51_ DDSSF 56_ LGGGG 61_ SRIDN 66_ TTTTH 71_ FAELW 76_ GHLDH 81_ TMFFQ 86_ DFRPF 91_ LSSSP 96_ LDQDN 101_ RANER 106_ GHQTH 111_ TDFWG 116_ ARPPR 121_ LPLGR 126_ RYRSR 131_ GSSRP 136_ DRSPA 141_ IEGIL 146_ QHIFA 151_ GFFAN 156_ SAIPG 161_ SPHPF 166_ SWSGM 171_ LHSNP 176_ GDYAW 181_ GQTGL 186_ DAIVT 191_ QLLGQ 196_ LENTG 201_ PPPAD 206_ KEKIT 211_ SLPTV 216_ TVTQE 221_ QVDMG 226_ LECPV 231_ CKEDY 236_ TVEEE 241_ VRQLP 246_ CNHFF 251_ HSSCI 256_ VPWLE 261_ LHDTC 266_ PVCRK 271_ SLNGE 276_ DSTRQ 281_ SQSTE 286_ ASASN 291_ RFSND 296_SQLHD
1: E3 ubiquitin-protein ligase that catalyzes the 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of various substrates and thereby plays a role in a number of signaling pathways including autophagy, innate immunity, cell proliferation and cell death (PubMed:20019814, PubMed:30689267). Plays a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4 through their polyubiquitination. Participates together with BST2 in antiviral immunity by facilitating the internalization of HIV-1 virions into intracellular vesicles leading to their lysosomal degradation (PubMed:20019814). Also possesses an antiviral activity independently of BST2 by promoting retroviral GAG proteins ubiquitination, redistribution to endo-lysosomal compartments and, ultimately, lysosomal degradation (PubMed:24852021). Catalyzes distinct types of ubiquitination on MAVS and STING1 at different phases of viral infection to promote innate antiviral response (PubMed:33139700). Mediates the 'Lys-48'-linked ubiquitination of MAVS leading to its proteasomal degradation and ubiquitinates STING1 via 'Lys-63'-linked polyubiquitination, critical for its oligomerization and the subsequent recruitment of TBK1 (PubMed:33139700). Plays a positive role in the autophagosome-lysosome fusion by interacting with STX17 and enhancing its stability without affecting 'Lys-48'- or 'Lys-63'-linked polyubiquitination levels, which in turn promotes autophagosome maturation (PubMed:32980859). Negatively regulates TLR-induced expression of proinflammatory cytokines by catalyzing 'Lys-11'-linked ubiquitination of RAB1A and RAB13 to inhibit post-ER trafficking of TLRs to the Golgi by RAB1A and subsequently from the Golgi apparatus to the cell surface by RAB13 (PubMed:35343654)