Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2)
1_MEPAP 6_ SEVRL 11_ AVREA 16_ IHALS 21_ SSEDG 26_ GHIFC 31_ TLESL 36_ KRYLG 41_ EMEPP 46_ ALPRE 51_ KEEFA 56_ SAHFS 61_ PVLRC 66_ LASRL 71_ SPAWL 76_ ELLPH 81_ GRLEE 86_ LWASF 91_ FLEGP 96_ ADQAF 101_ LVLME 106_ TIEGA 111_ AGPSF 116_ RLMKM 121_ ARLLA 126_ RFLRE 131_ GRLAV 136_ LMEAQ 141_ CRQQT 146_ QPGFI 151_ LLRET 156_ LLGKV 161_ VALPD 166_ HLGNR 171_ LQQEN 176_ LAEFF 181_ PQNYF 186_ RLLGE 191_ EVVRV 196_ LQAVV 201_ DSLQG 206_ GLDSS 211_ VSFVS 216_ QVLGK 221_ ACVHG 226_ RQQEI 231_ LGVLV 236_ PRLAA 241_ LTQGS 246_ YLHQR 251_ VCWRL 256_ VEQVP 261_ DRAME 266_ AVLTG 271_ LVEAA 276_ LGPEV 281_ LSRLL 286_ GNLVV 291_ KNKKA 296_ QFVMT 301_ QKLLF 306_ LQSRL 311_ TTPML 316_ QSLLG 321_ HLAMD 326_ SQRRP 331_ LLLQV 336_ LKELL 341_ ETWGS 346_ SSAIR 351_ HTPLP 356_ QQRHV 361_ SKAVL 366_ ICLAQ 371_ LGEPE 376_ LRDSR 381_ DELLA 386_ SMMAG 391_ VKCRL 396_ DSSLP 401_ PVRRL 406_ GMIVA 411_ EVVSA 416_ RIHPE 421_ GPPLK 426_ FQYEE 431_ DELSL 436_ ELLAL 441_ ASPQP 446_ AGDGA 451_ SEAGT 456_ SLVPA 461_ TAEPP 466_ AETPA 471_ EIVDG 476_ GVPQA 481_ QLAGS 486_ DSDLD 491_ SDDEF 496_ VPYDM 501_ SGDRE 506_ LKSSK 511_ APAYV 516_ RDCVE 521_ ALTTS 526_ EDIER 531_ WEAAL 536_ RALEG 541_ LVYRS 546_ PTATR 551_ EVSVE 556_ LAKVL 561_ LHLEE 566_ KTCVV 571_ GFAGL 576_ RQRAL 581_ VAVTV 586_ TDPAP 591_ VADYL 596_ TSQFY 601_ ALNYS 606_ LRQRM 611_ DILDV 616_ LTLAA 621_ QELSR 626_ PGCLG 631_ RTPQP 636_ GSPSP 641_ NTPCL 646_ PEAAV 651_ SQPGS 656_ AVASD 661_ WRVVV 666_ EERIR 671_ SKTQR 676_ LSKGG 681_ PRQGP 686_ AGSPS 691_ RFNSV 696_ AGHFF 701_ FPLLQ 706_ RFDRP 711_ LVTFD 716_ LLGED 721_ QLVLG 726_ RLAHT 731_ LGALM 736_ CLAVN 741_ TTVAV 746_ AMGKA 751_ LLEFV 756_ WALRF 761_ HIDAY 766_ VRQGL 771_ LSAVS 776_ SVLLS 781_ LPAAR 786_ LLEDL 791_ MDELL 796_ EARSW 801_ LADVA 806_ EKDPD 811_ EDCRT 816_ LALRA 821_ LLLLQ 826_ RLKNR 831_LLPPA
1: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation