Ribosomal biogenesis protein LAS1L (Protein LAS1 homolog)
1_MSWES 6_ GAGPG 11_ LGSQG 16_ MDLVW 21_ SAWYG 26_ KCVKG 31_ KGSLP 36_ LSAHG 41_ IVVAW 46_ LSRAE 51_ WDQVT 56_ VYLFC 61_ DDHKL 66_ QRYAL 71_ NRITV 76_ WRSRS 81_ GNELP 86_ LAVAS 91_ TADLI 96_ RCKLL 101_ DVTGG 106_ LGTDE 111_ LRLLY 116_ GMALV 121_ RFVNL 126_ ISERK 131_ TKFAK 136_ VPLKC 141_ LAQEV 146_ NIPDW 151_ IVDLR 156_ HELTH 161_ KKMPH 166_ INDCR 171_ RGCYF 176_ VLDWL 181_ QKTYW 186_ CRQLE 191_ NSLRE 196_ TWELE 201_ EFREG 206_ IEEED 211_ QEEDK 216_ NIVVD 221_ DITEQ 226_ KPEPQ 231_ DDGKS 236_ TESDV 241_ KADGD 246_ SKGSE 251_ EVDSH 256_ CKKAL 261_ SHKEL 266_ YERAR 271_ ELLVS 276_ YEEEQ 281_ FTVLE 286_ KFRYL 291_ PKAIK 296_ AWNNP 301_ SPRVE 306_ CVLAE 311_ LKGVT 316_ CENRE 321_ AVLDA 326_ FLDDG 331_ FLVPT 336_ FEQLA 341_ ALQIE 346_ YEDGQ 351_ TEVQR 356_ GEGTD 361_ PKSHK 366_ NVDLN 371_ DVLVP 376_ KPFSQ 381_ FWQPL 386_ LRGLH 391_ SQNFT 396_ QALLE 401_ RMLSE 406_ LPALG 411_ ISGIR 416_ PTYIL 421_ RWTVE 426_ LIVAN 431_ TKTGR 436_ NARRF 441_ SAGQW 446_ EARRG 451_ WRLFN 456_ CSASL 461_ DWPRM 466_ VESCL 471_ GSPCW 476_ ASPQL 481_ LRIIF 486_ KAMGQ 491_ GLPDE 496_ EQEKL 501_ LRICS 506_ IYTQS 511_ GENSL 516_ VQEGS 521_ EASPI 526_ GKSPY 531_ TLDSL 536_ YWSVK 541_ PASSS 546_ FGSEA 551_ KAQQQ 556_ EEQGS 561_ VNDVK 566_ EEEKE 571_ EKEVL 576_ PDQVE 581_ EEEEN 586_ DDQEE 591_ EEEDE 596_ DDEDD 601_ EEEDR 606_ MEVGP 611_ FSTGQ 616_ ESPTA 621_ ENARL 626_ LAQKR 631_ GALQG 636_ SAWQV 641_ SSEDV 646_ RWDTF 651_ PLGRM 656_ PGQTE 661_ DPAEL 666_ MLENY 671_ DTMYL 676_ LDQPV 681_ LEQRL 686_ EPSTC 691_ KTDTL 696_ GLSCG 701_ VGSGN 706_ CSNSS 711_ SSNFE 716_ GLLWS 721_ QGQLH 726_GLKTG
1: Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961)