E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)
1_MAAQQ 6_ RDCGG 11_ AAQLA 16_ GPAAE 21_ ADPLG 26_ RFTCP 31_ VCLEV 36_ YEKPV 41_ QVPCG 46_ HVFCS 51_ ACLQE 56_ CLKPK 61_ KPVCG 66_ VCRSA 71_ LAPGV 76_ RAVEL 81_ ERQIE 86_ STETS 91_ CHGCR 96_ KNFFL 101_ SKIRS 106_ HVATC 111_ SKYQN 116_ YIMEG 121_ VKATI 126_ KDASL 131_ QPRNV 136_ PNRYT 141_ FPCPY 146_ CPEKN 151_ FDQEG 156_ LVEHC 161_ KLFHS 166_ TDTKS 171_ VVCPI 176_ CASMP 181_ WGDPN 186_ YRSAN 191_ FREHI 196_ QRRHR 201_ FSYDT 206_ FVDYD 211_ VDEED 216_ MMNQV 221_LQRSI
1: E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as a negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Also acts as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis