DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9)
1_MFVLV 6_ EMVDT 11_ VRIPP 16_ WQFER 21_ KLNDS 26_ IAEEL 31_ NKKLA 36_ NKVVY 41_ NVGLC 46_ ICLFD 51_ ITKLE 56_ DAYVF 61_ PGDGA 66_ SHTKV 71_ HFRCV 76_ VFHPF 81_ LDEIL 86_ IGKIK 91_ GCSPE 96_ GVHVS 101_ LGFFD 106_ DILIP 111_ PESLQ 116_ QPAKF 121_ DEAEQ 126_ VWVWE 131_ YETEE 136_ GAHDL 141_ YMDTG 146_ EEIRF 151_ RVVDE 156_ SFVDT 161_ SPTGP 166_ SSADA 171_ TTSSE 176_ ELPKK 181_ EAPYT 186_ LVGSI 191_ SEPGL 196_GLLSW
1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity) (PubMed:33558764, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370)