Intraflagellar transport protein 25 homolog (Heat shock protein beta-11) (Hspb11) (Placental protein 25) (PP25)
1_MRKID 6_ LCLSS 11_ EGSEV 16_ ILATS 21_ SDEKH 26_ PPENI 31_ IDGNP 36_ ETFWT 41_ TTGMF 46_ PQEFI 51_ ICFHK 56_ HVRIE 61_ RLVIQ 66_ SYFVQ 71_ TLKIE 76_ KSTSK 81_ EPVDF 86_ EQWIE 91_ KDLVH 96_ TEGQL 101_ QNEEI 106_ VAHDG 111_ SATYL 116_ RFIIV 121_ SAFDH 126_ FASVH 131_ SVSAE 136_GTVVS
1: Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity)