Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89)
1_MSALE 6_ KSMHL 11_ GRLPS 16_ RPPLP 21_ GSGGS 26_ QSGAK 31_ MRMGP 36_ GRKRD 41_ FSPVP 46_ WSQYF 51_ ESMED 56_ VEVEN 61_ ETGKD 66_ TFRVY 71_ KSGSE 76_ GPVLL 81_ LLHGG 86_ GHSAL 91_ SWAVF 96_ TAAII 101_ SRVQC 106_ RIVAL 111_ DLRSH 116_ GETKV 121_ KNPED 126_ LSAET 131_ MAKDV 136_ GNVVE 141_ AMYGD 146_ LPPPI 151_ MLIGH 156_ SMGGA 161_ IAVHT 166_ ASSNL 171_ VPSLL 176_ GLCMI 181_ DVVEG 186_ TAMDA 191_ LNSMQ 196_ NFLRG 201_ RPKTF 206_ KSLEN 211_ AIEWS 216_ VKSGQ 221_ IRNLE 226_ SARVS 231_ MVGQV 236_ KQCEG 241_ ITSPE 246_ GSKSI 251_ VEGII 256_ EEEEE 261_ DEEGS 266_ ESISK 271_ RKKED 276_ DMETK 281_ KDHPY 286_ TWRIE 291_ LAKTE 296_ KYWDG 301_ WFRGL 306_ SNLFL 311_ SCPIP 316_ KLLLL 321_ AGVDR 326_ LDKDL 331_ TIGQM 336_ QGKFQ 341_ MQVLP 346_ QCGHA 351_ VHEDA 356_ PDKVA 361_ EAVAT 366_ FLIRH 371_ RFAEP 376_ IGGFQ 381_CVFPG
1: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme