Ankyrin repeat and SOCS box protein 4 (ASB-4)
1_MDGTT 6_ APVTK 11_ SGAAK 16_ LVKRN 21_ FLEAL 26_ KSNDF 31_ GKLKA 36_ ILIQR 41_ QIDVD 46_ TVFEV 51_ EDENM 56_ VLASY 61_ KQGYW 66_ LPSYK 71_ LKSSW 76_ ATGLH 81_ LSVLF 86_ GHVEC 91_ LLVLL 96_ DHNAT 101_ INCRP 106_ NGKTP 111_ LHVAC 116_ EMANV 121_ DCVKI 126_ LCDRG 131_ AKLNC 136_ YSLSG 141_ HTALH 146_ FCTTP 151_ SSILC 156_ AKQLV 161_ WRGAN 166_ VNMKT 171_ NNQDE 176_ ETPLH 181_ TAAHF 186_ GLSEL 191_ VAFYV 196_ EHGAI 201_ VDSVN 206_ AHMET 211_ PLAIA 216_ AYWAL 221_ RFKEQ 226_ EYSTE 231_ HHLVC 236_ RMLLD 241_ YKAEV 246_ NARDD 251_ DFKSP 256_ LHKAA 261_ WNCDH 266_ VLMHM 271_ MLEAG 276_ AEANL 281_ MDING 286_ CAAIQ 291_ YVLKV 296_ TSVRP 301_ AAQPE 306_ ICYQL 311_ LLNHG 316_ AARIY 321_ PPQFH 326_ KVIQA 331_ CHSCP 336_ KAIEV 341_ VVNAY 346_ EHIRW 351_ NTKWR 356_ RAIPD 361_ DDLEK 366_ YWDFY 371_ HSLFT 376_ VCCNS 381_ PRTLM 386_ HLSRC 391_ AIRRT 396_ LHNRC 401_ HRAIP 406_ LLSLP 411_ LSLKK 416_ YLLLE 421_PEGII
1: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity). Also acts as a negative regulator of GPS1, a component of the COP9 signalosome (CSN) multiprotein complex, thereby inhibiting the serine phosphorylation of IRS1 (By similarity). Regulates IRS4 levels by directing its degradation via ubiquitination and thereby decreases the downstream signal of IRS4 (PubMed:21955513). Plays a critical role during early vascular development and proper placentation. Mechanistically, negatively regulates the transcriptional regulator inhibitor of DNA binding 2/ID2 expression through polyubiquitination and proteasome dependent degradation (PubMed:24586788)