Ankyrin repeat and SOCS box protein 3 (ASB-3)
1_MDFTE 6_ AYADT 11_ CSTVG 16_ LAARE 21_ GNVKV 26_ LRKLL 31_ KKGRS 36_ VDVAD 41_ NRGWM 46_ PIHEA 51_ AYHNS 56_ VECLQ 61_ MLINA 66_ DSSEN 71_ YIKMK 76_ TFEGF 81_ CALHL 86_ AASQG 91_ HWKIV 96_ QILLE 101_ AGADP 106_ NATTL 111_ EETTP 116_ LFLAV 121_ ENGQI 126_ DVLRL 131_ LLQHG 136_ ANVNG 141_ SHSMC 146_ GWNSL 151_ HQASF 156_ QENAE 161_ IIKLL 166_ LRKGA 171_ NKECQ 176_ DDFGI 181_ TPLFV 186_ AAQYG 191_ KLESL 196_ SILIS 201_ SGANV 206_ NCQAL 211_ DKATP 216_ LFIAA 221_ QEGHT 226_ KCVEL 231_ LLSSG 236_ ADPDL 241_ YCNED 246_ SWQLP 251_ IHAAA 256_ QMGHT 261_ KILDL 266_ LIPLT 271_ NRACD 276_ TGLNK 281_ VSPVY 286_ SAVFG 291_ GHEDC 296_ LEILL 301_ RNGYS 306_ PDAQA 311_ CLVFG 316_ FSSPV 321_ CMAFQ 326_ KDCEF 331_ FGIVN 336_ ILLKY 341_ GAQIN 346_ ELHLA 351_ YCLKY 356_ EKFSI 361_ FRYFL 366_ RKGCS 371_ LGPWN 376_ HIYEF 381_ VNHAI 386_ KAQAK 391_ YKEWL 396_ PHLLV 401_ AGFDP 406_ LILLC 411_ NSWID 416_ SVSID 421_ TLIFT 426_ LEFTN 431_ WKTLA 436_ PAVER 441_ MLSAR 446_ ASNAW 451_ ILQQH 456_ IATVP 461_ SLTHL 466_ CRLEI 471_ RSSLK 476_ SERLR 481_ SDSYI 486_ SQLPL 491_ PRSLH 496_ NYLLY 501_ EDVLR 506_ MYEVP 511_ELAAI
1: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B (PubMed:15899873). Plays a role in the down-regulation of antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation (PubMed:39266719). Also destabilizes TRAF6 by enhancing its 'Lys-48'-linked polyubiquitination (PubMed:39162488)