Ankyrin repeat and SOCS box protein 1 (ASB-1)
1_MAEGG 6_ SPDGR 11_ AGPGS 16_ AGRNL 21_ KEWLR 26_ EQFCD 31_ HPLEH 36_ CEDTR 41_ LHDAA 46_ YVGDL 51_ QTLRS 56_ LLQEE 61_ SYRSR 66_ INEKS 71_ VWCCG 76_ WLPCT 81_ PLRIA 86_ ATAGH 91_ GSCVD 96_ FLIRK 101_ GAEVD 106_ LVDVK 111_ GQTAL 116_ YVAVV 121_ NGHLE 126_ STQIL 131_ LEAGA 136_ DPNGS 141_ RHHRS 146_ TPVYH 151_ ASRVG 156_ RADIL 161_ KALIR 166_ YGADV 171_ DVNHH 176_ LTPDV 181_ QPRFS 186_ RRLTS 191_ LVVCP 196_ LYISA 201_ AYHNL 206_ QCFRL 211_ LLLAG 216_ ANPDF 221_ NCNGP 226_ VNTQG 231_ FYRGS 236_ PGCVM 241_ DAVLR 246_ HGCEA 251_ AFVSL 256_ LVEFG 261_ ANLNL 266_ VKWES 271_ LGPES 276_ RGRRK 281_ VDPEA 286_ LQVFK 291_ EARSV 296_ PRTLL 301_ CLCRV 306_ AVRRA 311_ LGKHR 316_ LHLIP 321_ SLPLP 326_DPIKK
1: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:16325183). Mediates Notch-induced ubiquitination and degradation of TCF3/E2A and JAK2 (PubMed:21119685). Functions as a tumor suppressor by enhancing CHCHD3 'Lys-48'-linked ubiquitination, leading to inhibition of the CHCHD3/ROS signaling pathway (PubMed:39113857). Suppresses TAB2-linked 'Lys-48' polyubiquitination and consequently facilitates the initiation of NF-kappa-B and MAPK signaling cascades (PubMed:33431678). May play a role in testis development (By similarity)