E3 ubiquitin-protein ligase TRIM17 (EC 2.3.2.27) (RING finger protein 16) (RING-type E3 ubiquitin transferase TRIM17) (Testis RING finger protein) (Tripartite motif-containing protein 17)
1_MEAVE 6_ LARKL 11_ QEEAT 16_ CSICL 21_ DYFTD 26_ PVMTT 31_ CGHNF 36_ CRACI 41_ QLSWE 46_ KARGK 51_ KGRRK 56_ RKGSF 61_ PCPEC 66_ REMSP 71_ QRNLL 76_ PNRLL 81_ TKVAE 86_ MAQQH 91_ PGLQK 96_ QDLCQ 101_ EHHEP 106_ LKLFC 111_ QKDQS 116_ PICVV 121_ CRESR 126_ EHRLH 131_ RVLPA 136_ EEAVQ 141_ GYKLK 146_ LEEDM 151_ EYLRE 156_ QITRT 161_ GNLQA 166_ REEQS 171_ LAEWQ 176_ GKVKE 181_ RRERI 186_ VLEFE 191_ KMNLY 196_ LVEEE 201_ QRLLQ 206_ ALETE 211_ EEETA 216_ SRLRE 221_ SVACL 226_ DRQGH 231_ SLELL 236_ LLQLE 241_ ERSTQ 246_ GPLQM 251_ LQDMK 256_ EPLSR 261_ KNNVS 266_ VQCPE 271_ VAPPT 276_ RPRTV 281_ CRVPG 286_ QIEVL 291_ RGFLE 296_ DVVPD 301_ ATSAY 306_ PYLLL 311_ YESRQ 316_ RRYLG 321_ SSPEG 326_ SGFCS 331_ KDRFV 336_ AYPCA 341_ VGQTA 346_ FSSGR 351_ HYWEV 356_ GMNIT 361_ GDALW 366_ ALGVC 371_ RDNVS 376_ RKDRV 381_ PKCPE 386_ NGFWV 391_ VQLSK 396_ GTKYL 401_ STFSA 406_ LTPVM 411_ LMEPP 416_ SHMGI 421_ FLDFE 426_ AGEVS 431_ FYSVS 436_ DGSHL 441_ HTYSQ 446_ ATFPG 451_ PLQPF 456_ FCLGA 461_ PKSGQ 466_ MVIST 471_VTMWV
1: E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation (PubMed:19358823, PubMed:22023800, PubMed:27562068). Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation (PubMed:22023800). Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (PubMed:27562068). Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (By similarity). Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (PubMed:19358823)