Mitochondrial import inner membrane translocase subunit Tim22 (Testis-expressed protein 4)
1_MAAAA 6_ PNAGG 11_ SAPET 16_ AGSAE 21_ APLQY 26_ SLLLQ 31_ YLVGD 36_ KRQPR 41_ LLEPG 46_ SLGGI 51_ PSPAK 56_ SEEQK 61_ MIEKA 66_ MESCA 71_ FKAAL 76_ ACVGG 81_ FVLGG 86_ AFGVF 91_ TAGID 96_ TNVGF 101_ DPKDP 106_ YRTPT 111_ AKEVL 116_ KDMGQ 121_ RGMSY 126_ AKNFA 131_ IVGAM 136_ FSCTE 141_ CLIES 146_ YRGTS 151_ DWKNS 156_ VISGC 161_ ITGGA 166_ IGFRA 171_ GLKAG 176_ AIGCG 181_ GFAAF 186_SAAID
1: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity)