AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin)
1_MIKFF 6_ LMVNK 11_ QGQTR 16_ LSKYY 21_ EHVDI 26_ NKRTL 31_ LETEV 36_ IKSCL 41_ SRSNE 46_ QCSFI 51_ EYKDF 56_ KLIYR 61_ QYAAL 66_ FIVVG 71_ VNDTE 76_ NEMAI 81_ YEFIH 86_ NFVEV 91_ LDEYF 96_ SRVSE 101_ LDIMF 106_ NLDKV 111_ HIILD 116_ EMVLN 121_ GCIVE 126_ TNRAR 131_ ILAPL 136_LILDK
1: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable)