RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase)
1_MEVPA 6_ AGRVP 11_ AEGAP 16_ TAAVA 21_ EVRCP 26_ GPAPL 31_ RLLEW 36_ RVAAG 41_ AAVRI 46_ GSVLA 51_ VFEAA 56_ ASAQS 61_ SGASQ 66_ SRVAS 71_ GGCVR 76_ PARPE 81_ RRLRS 86_ ERAGV 91_ VRELC 96_ AQPGQ 101_ VVAPG 106_ AVLVR 111_ LEGCS 116_ HPVVM 121_ KGLCA 126_ ECGQD 131_ LTQLQ 136_ SKNGK 141_ QQVPL 146_ STATV 151_ SMVHS 156_ VPELM 161_ VSSEQ 166_ AEQLG 171_ REDQQ 176_ RLHRN 181_ RKLVL 186_ MVDLD 191_ QTLIH 196_ TTEQH 201_ CQQMS 206_ NKGIF 211_ HFQLG 216_ RGEPM 221_ LHTRL 226_ RPHCK 231_ DFLEK 236_ IAKLY 241_ ELHVF 246_ TFGSR 251_ LYAHT 256_ IAGFL 261_ DPEKK 266_ LFSHR 271_ ILSRD 276_ ECIDP 281_ FSKTG 286_ NLRNL 291_ FPCGD 296_ SMVCI 301_ IDDRE 306_ DVWKF 311_ APNLI 316_ TVKKY 321_ VYFQG 326_ TGDMN 331_ APPGS 336_ RESQT 341_ RKKVN 346_ HSRGT 351_ EVSEP 356_ SPPVR 361_ DPEGV 366_ TQAPG 371_ VEPSN 376_ GLEKP 381_ ARELN 386_ GSEAA 391_ TPRDS 396_ PRPGK 401_ PDERD 406_ IWPPA 411_ QAPTS 416_ SQELA 421_ GAPEP 426_ QGSCA 431_ QGGRV 436_ APGQR 441_ PAQGA 446_ TGTDL 451_ DFDLS 456_ SDSES 461_ SSESE 466_ GTKSS 471_ SSASD 476_ GESEG 481_ KRGRQ 486_ KPKAA 491_ PEGAG 496_ ALAQG 501_ SSLEP 506_ GRPAA 511_ PSLPG 516_ EAEPG 521_ AHAPD 526_ KEPEL 531_ GGQEE 536_ GERDG 541_ LCGLG 546_ NGCAD 551_ RKEAE 556_ TESQN 561_ SELSG 566_ VTAGE 571_ SLDQS 576_ MEEEE 581_ EEDTD 586_ EDDHL 591_ IYLEE 596_ ILVRV 601_ HTDYY 606_ AKYDR 611_ YLNKE 616_ IEEAP 621_ DIRKI 626_ VPELK 631_ SKVLA 636_ DVAII 641_ FSGLH 646_ PTNFP 651_ IEKTR 656_ EHYHA 661_ TALGA 666_ KILTR 671_ LVLSP 676_ DAPDR 681_ ATHLI 686_ AARAG 691_ TEKVL 696_ QAQEC 701_ GHLHV 706_ VNPDW 711_ LWSCL 716_ ERWDK 721_ VEEQL 726_ FPLRD 731_ DHTKA 736_ QRENS 741_ PAAFP 746_ DREGV 751_ PPTAL 756_ FHPMP 761_ VLPKA 766_ QPGPE 771_ VRIYD 776_ SNTGK 781_ LIRTG 786_ ARGPP 791_ APSSS 796_ LPIRQ 801_ EPSSF 806_ RAVPP 811_ PQPQM 816_ FGEEL 821_ PDAQD 826_ GEQPG 831_ PSRRK 836_ RQPSM 841_ SETMP 846_ LYTLC 851_ KEDLE 856_ SMDKE 861_ VDDIL 866_ GEGSD 871_ DSDSE 876_ KRRPE 881_ EQEEE 886_ PQPRK 891_ PGTRR 896_ ERTLG 901_ APASS 906_ ERSAA 911_ GGRGP 916_ RGHKR 921_ KLNEE 926_ DAASE 931_ SSRES 936_ SNEDE 941_ GSSSE 946_ ADEMA 951_ KALEA 956_ELNDL
1: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation