FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16)
1_MAVTL 6_ DKDAY 11_ YRRVK 16_ RLYSN 21_ WRKGE 26_ DEYAN 31_ VDAIV 36_ VSVGV 41_ DEEIV 46_ YAKST 51_ ALQTW 56_ LFGYE 61_ LTDTI 66_ MVFCD 71_ DKIIF 76_ MASKK 81_ KVEFL 86_ KQIAN 91_ TKGNE 96_ NANGA 101_ PAITL 106_ LIREK 111_ NESNK 116_ SSFDK 121_ MIEAI 126_ KESKN 131_ GKKIG 136_ VFSKD 141_ KFPGE 146_ FMKSW 151_ NDCLN 156_ KEGFD 161_ KIDIS 166_ AVVAY 171_ TIAVK 176_ EDGEL 181_ NLMKK 186_ AASIT 191_ SEVFN 196_ KFFKE 201_ RVMEI 206_ VDADE 211_ KVRHS 216_ KLAES 221_ VEKAI 226_ EEKKY 231_ LAGAD 236_ PSTVE 241_ MCYPP 246_ IIQSG 251_ GNYNL 256_ KFSVV 261_ SDKNH 266_ MHFGA 271_ ITCAM 276_ GIRFK 281_ SYCSN 286_ LVRTL 291_ MVDPS 296_ QEVQE 301_ NYNFL 306_ LQLQE 311_ ELLKE 316_ LRHGV 321_ KICDV 326_ YNAVM 331_ DVVKK 336_ QKPEL 341_ LNKIT 346_ KNLGF 351_ GMGIE 356_ FREGS 361_ LVINS 366_ KNQYK 371_ LKKGM 376_ VFSIN 381_ LGFSD 386_ LTNKE 391_ GKKPE 396_ EKTYA 401_ LFIGD 406_ TVLVD 411_ EDGPA 416_ TVLTS 421_ VKKKV 426_ KNVGI 431_ FLKNE 436_ DEEEE 441_ EEEKD 446_ EAEDL 451_ LGRGS 456_ RAALL 461_ TERTR 466_ NEMTA 471_ EEKRR 476_ AHQKE 481_ LAAQL 486_ NEEAK 491_ RRLTE 496_ QKGEQ 501_ QIQKA 506_ RKSNV 511_ SYKNP 516_ SLMPK 521_ EPHIR 526_ EMKIY 531_ IDKKY 536_ ETVIM 541_ PVFGI 546_ ATPFH 551_ IATIK 556_ NISMS 561_ VEGDY 566_ TYLRI 571_ NFYCP 576_ GSALG 581_ RNEGN 586_ IFPNP 591_ EATFV 596_ KEITY 601_ RASNI 606_ KAPGE 611_ QTVPA 616_ LNLQN 621_ AFRII 626_ KEVQK 631_ RYKTR 636_ EAEEK 641_ EKEGI 646_ VKQDS 651_ LVINL 656_ NRSNP 661_ KLKDL 666_ YIRPN 671_ IAQKR 676_ MQGSL 681_ EAHVN 686_ GFRFT 691_ SVRGD 696_ KVDIL 701_ YNNIK 706_ HALFQ 711_ PCDGE 716_ MIIVL 721_ HFHLK 726_ NAIMF 731_ GKKRH 736_ TDVQF 741_ YTEVG 746_ EITTD 751_ LGKHQ 756_ HMHDR 761_ DDLYA 766_ EQMER 771_ EMRHK 776_ LKTAF 781_ KNFIE 786_ KVEAL 791_ TKEEL 796_ EFEVP 801_ FRDLG 806_ FNGAP 811_ YRSTC 816_ LLQPT 821_ SSALV 826_ NATEW 831_ PPFVV 836_ TLDEV 841_ ELIHF 846_ ERVQF 851_ HLKNF 856_ DMVIV 861_ YKDYS 866_ KKVTM 871_ INAIP 876_ VASLD 881_ PIKEW 886_ LNSCD 891_ LKYTE 896_ GVQSL 901_ NWTKI 906_ MKTIV 911_ DDPEG 916_ FFEQG 921_ GWSFL 926_ EPEGE 931_ GSDAE 936_ EGDSE 941_ SEIED 946_ ETFNP 951_ SEDDY 956_ EEEEE 961_ DSDED 966_ YSSEA 971_ EESDY 976_ SKESL 981_ GSEEE 986_ SGKDW 991_ DELEE 996_ EARKA 1001_ DRESR 1006_ YEEEE 1011_ EQSRS 1016_ MSRKR 1021_ KASVH 1026_ SSGRG 1031_ SNRGS 1036_ RHSSA 1041_PPKKK
1: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II)