Claudin-16 (Paracellin-1) (PCLN-1)
1_MRDLL 6_ QYIAC 11_ FFAFF 16_ SAGFL 21_ IVATW 26_ TDCWM 31_ VNADD 36_ SLEVS 41_ TKCRG 46_ LWWEC 51_ VTNAF 56_ DGIRT 61_ CDEYD 66_ SILAE 71_ HPLKL 76_ VVTRA 81_ LMITA 86_ DILAG 91_ FGFLT 96_ LLLGL 101_ DCVKF 106_ LPDEP 111_ YIKVR 116_ ICFVA 121_ GATLL 126_ IAGTP 131_ GIIGS 136_ VWYAV 141_ DVYVE 146_ RSTLV 151_ LHNIF 156_ LGIQY 161_ KFGWS 166_ CWLGM 171_ AGSLG 176_ CFLAG 181_ AVLTC 186_ CLYLF 191_ KDVGP 196_ ERNYP 201_ YSLRK 206_ AYSAA 211_ GVSMA 216_ KSYSA 221_ PRTET 226_AKMYA
1: Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:16234325, PubMed:18188451, PubMed:28028216). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (PubMed:10390358, PubMed:11518780, PubMed:14628289, PubMed:16528408, PubMed:28028216)