Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1)
1_MKRAH 6_ PEYSS 11_ SDSEL 16_ DETIE 21_ VEKES 26_ ADENG 31_ NLSSA 36_ LGSMS 41_ PTTSS 46_ QILAR 51_ KRRRG 56_ IIEKR 61_ RRDRI 66_ NNSLS 71_ ELRRL 76_ VPSAF 81_ EKQGS 86_ AKLEK 91_ AEILQ 96_ MTVDH 101_ LKMLH 106_ TAGGK 111_ GYFDA 116_ HALAM 121_ DYRSL 126_ GFREC 131_ LAEVA 136_ RYLSI 141_ IEGLD 146_ ASDPL 151_ RVRLV 156_ SHLNN 161_ YASQR 166_ EAASG 171_ AHAGL 176_ GHIPW 181_ GTVFG 186_ HHPHI 191_ AHPLL 196_ LPQNG 201_ HGNAG 206_ TTASP 211_ TEPHH 216_ QGRLG 221_ SAHPE 226_ APALR 231_ APPSG 236_ SLGPV 241_ LPVVT 246_ SASKL 251_ SPPLL 256_ SSVAS 261_ LSAFP 266_ FSFGS 271_ FHLLS 276_ PNALS 281_ PSAPT 286_ QAANL 291_ GKPYR 296_PWGTE
1: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737)