Pleckstrin homology-like domain family A member 3 (TDAG51/Ipl homolog 1)
1_MTAAA 6_ TATVL 11_ KEGVL 16_ EKRSG 21_ GLLQL 26_ WKRKR 31_ CVLTE 36_ RGLQL 41_ FEAKG 46_ TGGRP 51_ KELSF 56_ ARIKA 61_ VECVE 66_ STGRH 71_ IYFTL 76_ VTEGG 81_ GEIDF 86_ RCPLE 91_ DPGWN 96_ AQITL 101_ GLVKF 106_ KNQQA 111_ IQTVR 116_ ARQSL 121_GTGTL
1: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor