Meiotic recombination protein SPO11 (EC 5.6.2.2) (Cancer/testis antigen 35) (CT35)
1_MAFAP 6_ MGPEA 11_ SFFDV 16_ LDRHR 21_ ESLLA 26_ ALRRG 31_ GREPP 36_ TGGSR 41_ LASSS 46_ EVLAS 51_ IENII 56_ QDIIT 61_ SLARN 66_ EAPAF 71_ TIDNR 76_ SSWEN 81_ IKFED 86_ SVGLQ 91_ MVSHC 96_ TTRKI 101_ KSDSP 106_ KSAQK 111_ FSLIL 116_ KILSM 121_ IYKLV 126_ QSNTY 131_ ATKRD 136_ IYYTD 141_ SQLFG 146_ NQTVV 151_ DNIIN 156_ DISCM 161_ LKVSR 166_ RSLHI 171_ LSTSK 176_ GLIAG 181_ NLRYI 186_ EEDGT 191_ KVNCT 196_ CGATA 201_ VAVPS 206_ NIQGI 211_ RNLVT 216_ DAKFV 221_ LIVEK 226_ DATFQ 231_ RLLDD 236_ NFCNK 241_ LSPCI 246_ MITGK 251_ GVPDL 256_ NTRLL 261_ VKKLW 266_ DTFHV 271_ PVFTL 276_ VDADP 281_ HGIEI 286_ MCIYK 291_ YGSMS 296_ MSFEA 301_ HHLTV 306_ PAIRW 311_ LGLLP 316_ SDLKR 321_ LNVPK 326_ DSLIP 331_ LTKRD 336_ QMKLD 341_ SILRR 346_ PYVTC 351_ QPFWR 356_ KEMEI 361_ MADSK 366_ MKAEI 371_ QALTF 376_ LSSDY 381_ LSRVY 386_ LPNKL 391_KFGGW
1: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2