Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)
1_MTGNA 6_ GEWCL 11_ MESDP 16_ GVFTE 21_ LIKGF 26_ GCRGA 31_ QVEEI 36_ WSLEP 41_ ENFEK 46_ LKPVH 51_ GLIFL 56_ FKWQP 61_ GEEPA 66_ GSVVQ 71_ DSRLD 76_ TIFFA 81_ KQVIN 86_ NACAT 91_ QAIVS 96_ VLLNC 101_ THQDV 106_ HLGET 111_ LSEFK 116_ EFSQS 121_ FDAAM 126_ KGLAL 131_ SNSDV 136_ IRQVH 141_ NSFAR 146_ QQMFE 151_ FDTKT 156_ SAKEE 161_ DAFHF 166_ VSYVP 171_ VNGRL 176_ YELDG 181_ LREGP 186_ IDLGA 191_ CNQDD 196_ WISAV 201_ RPVIE 206_ KRIQK 211_ YSEGE 216_ IRFNL 221_ MAIVS 226_ DRKMI 231_ YEQKI 236_ AELQR 241_ QLAEE 246_ EPMDT 251_ DQGNS 256_ MLSAI 261_ QSEVA 266_ KNQML 271_ IEEEV 276_ QKLKR 281_ YKIEN 286_ IRRKH 291_ NYLPF 296_ IMELL 301_ KTLAE 306_ HQQLI 311_ PLVEK 316_ AKEKQ 321_NAKKA
1: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1