CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
1_MVDYI 6_ VEYDY 11_ DAVHD 16_ DELTI 21_ RVGEI 26_ IRNVK 31_ KLQEE 36_ GWLEG 41_ ELNGR 46_ RGMFP 51_ DNFVK 56_ EIKRE 61_ TEFKD 66_ DSLPI 71_ KRERH 76_ GNVAS 81_ LVQRI 86_ STYGL 91_ PAGGI 96_ QPHPQ 101_ TKNIK 106_ KKTKK 111_ RQCKV 116_ LFEYI 121_ PQNED 126_ ELELK 131_ VGDII 136_ DINEE 141_ VEEGW 146_ WSGTL 151_ NNKLG 156_ LFPSN 161_ FVKEL 166_ EVTDD 171_ GETHE 176_ AQDDS 181_ ETVLA 186_ GPTSP 191_ IPSLG 196_ NVSET 201_ ASGSV 206_ TQPKK 211_ IRGIG 216_ FGDIF 221_ KEGSV 226_ KLRTR 231_ TSSSE 236_ TEEKK 241_ PEKPL 246_ ILQSL 251_ GPKTQ 256_ SVEIT 261_ KTDTE 266_ GKIKA 271_ KEYCR 276_ TLFAY 281_ EGTNE 286_ DELTF 291_ KEGEI 296_ IHLIS 301_ KETGE 306_ AGWWR 311_ GELNG 316_ KEGVF 321_ PDNFA 326_ VQINE 331_ LDKDF 336_ PKPKK 341_ PPPPA 346_ KAPAP 351_ KPELI 356_ AAEKK 361_ YFSLK 366_ PEEKD 371_ EKSTL 376_ EQKPS 381_ KPAAP 386_ QVPPK 391_ KPTPP 396_ TKASN 401_ LLRSS 406_ GTVYP 411_ KRPEK 416_ PVPPP 421_ PPIAK 426_ INGEV 431_ SSISS 436_ KFETE 441_ PVSKL 446_ KLDSE 451_ QLPLR 456_ PKSVD 461_ FDSLT 466_ VRTSK 471_ ETDVV 476_ NFDDI 481_ ASSEN 486_ LLHLT 491_ ANRPK 496_ MPGRR 501_ LPGRF 506_ NGGHS 511_ PTHSP 516_ EKILK 521_ LPKEE 526_ DSANL 531_ KPSEL 536_ KKDTC 541_ YSPKP 546_ SVYLS 551_ TPSSA 556_ SKANT 561_ TAFLT 566_ PLEIK 571_ AKVET 576_ DDVKK 581_ NSLDE 586_ LRAQI 591_ IELLC 596_ IVEAL 601_ KKDHG 606_ KELEK 611_ LRKDL 616_ EEEKT 621_ MRSNL 626_ EMEIE 631_KLKKA
1: Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260)