Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)
1_MEGAK 6_ PTLQL 11_ VYQAV 16_ QALYH 21_ DPDPS 26_ GKERA 31_ SFWLG 36_ ELQRS 41_ VHAWE 46_ ISDQL 51_ LQIRQ 56_ DVESC 61_ YFAAQ 66_ TMKMK 71_ IQTSF 76_ YELPT 81_ DSHAS 86_ LRDSL 91_ LTHIQ 96_ NLKDL 101_ SPVIV 106_ TQLAL 111_ AIADL 116_ ALQMP 121_ SWKGC 126_ VQTLV 131_ EKYSN 136_ DVTSL 141_ PFLLE 146_ ILTVL 151_ PEEVH 156_ SRSLR 161_ IGANR 166_ RTEII 171_ EDLAF 176_ YSSTV 181_ VSLLM 186_ TCVEK 191_ AGTDE 196_ KMLMK 201_ VFRCL 206_ GSWFN 211_ LGVLD 216_ SNFMA 221_ NNKLL 226_ ALLFE 231_ VLQQD 236_ KTSSN 241_ LHEAA 246_ SDCVC 251_ SALYA 256_ IENVE 261_ TNLPL 266_ AMQLF 271_ QGVLT 276_ LETAY 281_ HMAVA 286_ REDLD 291_ KVLNY 296_ CRIFT 301_ ELCET 306_ FLEKI 311_ VCTPG 316_ QGLGD 321_ LRTLE 326_ LLLIC 331_ AGHPQ 336_ YEVVE 341_ ISFNF 346_ WYRLG 351_ EHLYK 356_ TNDEV 361_ IHGIF 366_ KAYIQ 371_ RLLHA 376_ LARHC 381_ QLEPD 386_ HEGVP 391_ EETDD 396_ FGEFR 401_ MRVSD 406_ LVKDL 411_ IFLIG 416_ SMECF 421_ AQLYS 426_ TLKEG 431_ NPPWE 436_ VTEAV 441_ LFIMA 446_ AIAKS 451_ VDPEN 456_ NPTLV 461_ EVLEG 466_ VVRLP 471_ ETVHT 476_ AVRYT 481_ SIELV 486_ GEMSE 491_ VVDRN 496_ PQFLD 501_ PVLGY 506_ LMKGL 511_ CEKPL 516_ ASAAA 521_ KAIHN 526_ ICSVC 531_ RDHMA 536_ QHFNG 541_ LLEIA 546_ RSLDS 551_ FLLSP 556_ EAAVG 561_ LLKGT 566_ ALVLA 571_ RLPLD 576_ KITEC 581_ LSELC 586_ SVQVM 591_ ALKKL 596_ LSQEP 601_ SNGIS 606_ SDPTV 611_ FLDRL 616_ AVIFR 621_ HTNPI 626_ VENGQ 631_ THPCQ 636_ KVIQE 641_ IWPVL 646_ SETLN 651_ KHRAD 656_ NRIVE 661_ RCCRC 666_ LRFAV 671_ RCVGK 676_ GSAAL 681_ LQPLV 686_ TQMVN 691_ VYHVH 696_ QHSCF 701_ LYLGS 706_ ILVDE 711_ YGMEE 716_ GCRQG 721_ LLDML 726_ QALCI 731_ PTFQL 736_ LEQQN 741_ GLQNH 746_ PDTVD 751_ DLFRL 756_ ATRFI 761_ QRSPV 766_ TLLRS 771_ QVVIP 776_ ILQWA 781_ IASTT 786_ LDHRD 791_ ANCSV 796_ MRFLR 801_ DLIHT 806_ GVAND 811_ HEEDF 816_ ELRKE 821_ LIGQV 826_ MNQLG 831_ QQLVS 836_ QLLHT 841_ CCFCL 846_ PPYTL 851_ PDVAE 856_ VLWEI 861_ MQVDR 866_ PTFCR 871_ WLENS 876_ LKGLP 881_ KETTV 886_ GAVTV 891_ THKQL 896_ TDFHK 901_ QVTSA 906_ EECKQ 911_ VCWAL 916_RDFTR
1: Importin, which transports target proteins into the nucleus (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PubMed:30916345, PubMed:31465518). The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PubMed:23878195, PubMed:24449914). Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PubMed:23878195, PubMed:24449914)
2: (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus (PubMed:18722123, PubMed:21901095, PubMed:22398280, PubMed:29329553). Required for a nuclear maturation step of HIV-1 prior to integration (PubMed:21901095, PubMed:22398280)