Mitochondrial import inner membrane translocase subunit Tim13
1_MEGGF 6_ GSDFG 11_ GSGSG 16_ KLDPG 21_ LIMEQ 26_ VKVQI 31_ AVANA 36_ QELLQ 41_ RMTDK 46_ CFRKC 51_ IGKPG 56_ GSLDN 61_ SEQKC 66_ IAMCM 71_ DRYMD 76_ AWNTV 81_ SRAYN 86_SRLQR
1: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins