Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97)
1_MERAP 6_ PDGPL 11_ NASGA 16_ LAGEA 21_ AAAGG 26_ ARGFS 31_ AAWTA 36_ VLAAL 41_ MALLI 46_ VATVL 51_ GNALV 56_ MLAFV 61_ ADSSL 66_ RTQNN 71_ FFLLN 76_ LAISD 81_ FLVGA 86_ FCIPL 91_ YVPYV 96_ LTGRW 101_ TFGRG 106_ LCKLW 111_ LVVDY 116_ LLCTS 121_ SAFNI 126_ VLISY 131_ DRFLS 136_ VTRAV 141_ SYRAQ 146_ QGDTR 151_ RAVRK 156_ MLLVW 161_ VLAFL 166_ LYGPA 171_ ILSWE 176_ YLSGG 181_ SSIPE 186_ GHCYA 191_ EFFYN 196_ WYFLI 201_ TASTL 206_ EFFTP 211_ FLSVT 216_ FFNLS 221_ IYLNI 226_ QRRTR 231_ LRLDG 236_ AREAA 241_ GPEPP 246_ PEAQP 251_ SPPPP 256_ PGCWG 261_ CWQKG 266_ HGEAM 271_ PLHRY 276_ GVGEA 281_ AVGAE 286_ AGEAT 291_ LGGGG 296_ GGGSV 301_ ASPTS 306_ SSGSS 311_ SRGTE 316_ RPRSL 321_ KRGSK 326_ PSASS 331_ ASLEK 336_ RMKMV 341_ SQSFT 346_ QRFRL 351_ SRDRK 356_ VAKSL 361_ AVIVS 366_ IFGLC 371_ WAPYT 376_ LLMII 381_ RAACH 386_ GHCVP 391_ DYWYE 396_ TSFWL 401_ LWANS 406_ AVNPV 411_ LYPLC 416_ HHSFR 421_ RAFTK 426_ LLCPQ 431_ KLKIQ 436_PHSSL
1: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization