Origin recognition complex subunit 6
1_MGSEL 6_ IGRLA 11_ PRLGL 16_ AEPDM 21_ LRKAE 26_ EYLRL 31_ SRVKC 36_ VGLSA 41_ RTTET 46_ SSAVM 51_ CLDLA 56_ ASWMK 61_ CPLDR 66_ AYLIK 71_ LSGLN 76_ KETYQ 81_ SCLKS 86_ FECLL 91_ GLNSN 96_ IGIRD 101_ LAVQF 106_ SCIEA 111_ VNMAS 116_ KILKS 121_ YESSL 126_ PQTQQ 131_ VDLDL 136_ SRPLF 141_ TSAAL 146_ LSACK 151_ ILKLK 156_ VDKNK 161_ MVATS 166_ GVKKA 171_ IFDRL 176_ CKQLE 181_ KIGQQ 186_ VDREP 191_ GDVAT 196_ PPRKR 201_ KKIVV 206_ EAPAK 211_ EMEKV 216_ EEMPH 221_ KPQKD 226_ EDLTQ 231_ DYEEW 236_ KRKIL 241_ ENAAS 246_AQKAT
1: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3