Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B)
1_MAAEL 6_ SMGPE 11_ LPTSP 16_ LAMEY 21_ VNDFD 26_ LLKFD 31_ VKKEP 36_ LGRAE 41_ RPGRP 46_ CTRLQ 51_ PAGSV 56_ SSTPL 61_ STPCS 66_ SVPSS 71_ PSFSP 76_ TEQKT 81_ HLEDL 86_ YWMAS 91_ NYQQM 96_ NPEAL 101_ NLTPE 106_ DAVEA 111_ LIGSH 116_ PVPQP 121_ LQSFD 126_ SFRGA 131_ HHHHH 136_ HHHPH 141_ PHHAY 146_ PGAGV 151_ AHDEL 156_ GPHAH 161_ PHHHH 166_ HHQAS 171_ PPPSS 176_ AASPA 181_ QQLPT 186_ SHPGP 191_ GPHAT 196_ ASATA 201_ AGGNG 206_ SVEDR 211_ FSDDQ 216_ LVSMS 221_ VRELN 226_ RHLRG 231_ FTKDE 236_ VIRLK 241_ QKRRT 246_ LKNRG 251_ YAQSC 256_ RYKRV 261_ QQKHH 266_ LENEK 271_ TQLIQ 276_ QVEQL 281_ KQEVS 286_ RLARE 291_ RDAYK 296_ VKCEK 301_ LANSG 306_ FREAG 311_ STSDS 316_PSSPE
1: Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity)