Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]
1_MKQSP 6_ ALAPE 11_ ERCRR 16_ AGSPK 21_ PVLRA 26_ DDNNM 31_ GNGCS 36_ QKLAT 41_ ANLLR 46_ FLLLV 51_ LIPCI 56_ CALVL 61_ LLVIL 66_ LSYVG 71_ TLQKV 76_ YFKSN 81_ GSEPL 86_ VTDGE 91_ IQGSD 96_ VILTN 101_ TIYNQ 106_ STVVS 111_ TAHPD 116_ QHVPA 121_ WTTDA 126_ SLPGD 131_ QSHRN 136_ TSACM 141_ NITHS 146_ QCQML 151_ PYHAT 156_ LTPLL 161_ SVVRN 166_ MEMEK 171_ FLKFF 176_ TYLHR 181_ LSCYQ 186_ HIMLF 191_ GCTLA 196_ FPECI 201_ IDGDD 206_ SHGLL 211_ PCRSF 216_ CEAAK 221_ EGCES 226_ VLGMV 231_ NYSWP 236_ DFLRC 241_ SQFRN 246_ QTESS 251_ NVSRI 256_ CFSPQ 261_ QENGK 266_ QLLCG 271_ RGENF 276_ LCASG 281_ ICIPG 286_ KLQCN 291_ GYNDC 296_ DDWSD 301_ EAHCN 306_ CSENL 311_ FHCHT 316_ GKCLN 321_ YSLVC 326_ DGYDD 331_ CGDLS 336_ DEQNC 341_ DCNPT 346_ TEHRC 351_ GDGRC 356_ IAMEW 361_ VCDGD 366_ HDCVD 371_ KSDEV 376_ NCSCH 381_ SQGLV 386_ ECRNG 391_ QCIPS 396_ TFQCD 401_ GDEDC 406_ KDGSD 411_ EENCS 416_ VIQTS 421_ CQEGD 426_ QRCLY 431_ NPCLD 436_ SCGGS 441_ SLCDP 446_ NNSLN 451_ NCSQC 456_ EPITL 461_ ELCMN 466_ LPYNS 471_ TSYPN 476_ YFGHR 481_ TQKEA 486_ SISWE 491_ SSLFP 496_ ALVQT 501_ NCYKY 506_ LMFFS 511_ CTILV 516_ PKCDV 521_ NTGEH 526_ IPPCR 531_ ALCEH 536_ SKERC 541_ ESVLG 546_ IVGLQ 551_ WPEDT 556_ DCSQF 561_ PEENS 566_ DNQTC 571_ LMPDE 576_ YVEEC 581_ SPSHF 586_ KCRSG 591_ QCVLA 596_ SRRCD 601_ GQADC 606_ DDDSD 611_ EENCG 616_ CKERD 621_ LWECP 626_ SNKQC 631_ LKHTV 636_ ICDGF 641_ PDCPD 646_ YMDEK 651_ NCSFC 656_ QDDEL 661_ ECANH 666_ ACVSR 671_ DLWCD 676_ GEADC 681_ SDSSD 686_ EWDCV 691_ TLSIN 696_ VNSSS 701_ FLMVH 706_ RAATE 711_ HHVCA 716_ DGWQE 721_ ILSQL 726_ ACKQM 731_ GLGEP 736_ SVTKL 741_ IQEQE 746_ KEPRW 751_ LTLHS 756_ NWESL 761_ NGTTL 766_ HELLV 771_ NGQSC 776_ ESRSK 781_ ISLLC 786_ TKQDC 791_ GRRPA 796_ ARMNK 801_ RILGG 806_ RTSRP 811_ GRWPW 816_ QCSLQ 821_ SEPSG 826_ HICGC 831_ VLIAK 836_ KWVLT 841_ VAHCF 846_ EGREN 851_ AAVWK 856_ VVLGI 861_ NNLDH 866_ PSVFM 871_ QTRFV 876_ KTIIL 881_ HPRYS 886_ RAVVD 891_ YDISI 896_ VELSE 901_ DISET 906_ GYVRP 911_ VCLPN 916_ PEQWL 921_ EPDTY 926_ CYITG 931_ WGHMG 936_ NKMPF 941_ KLQEG 946_ EVRII 951_ SLEHC 956_ QSYFD 961_ MKTIT 966_ TRMIC 971_ AGYES 976_ GTVDS 981_ CMGDS 986_ GGPLV 991_ CEKPG 996_ GRWTL 1001_ FGLTS 1006_ WGSVC 1011_ FSKVL 1016_ GPGVY 1021_ SNVSY 1026_ FVEWI 1031_ KRQIY 1036_IQTFL
1: Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity)
2: Has weaker endopeptidase activity compared to isoform 1