Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1)
1_MPNDE 6_ AFSKP 11_ STPSE 16_ APHAP 21_ GVPPQ 26_ GRAGG 31_ FGKAS 36_ GALVG 41_ AASGS 46_ SAGGS 51_ SRGGG 56_ SGSGA 61_ SDLGA 66_ GSKKS 71_ PRLPK 76_ CARCR 81_ NHGYA 86_ SPLKG 91_ HKRFC 96_ MWRDC 101_ QCKKC 106_ NLIAE 111_ RQRVM 116_ AAQVA 121_ LRRQQ 126_ AQEEE 131_ LGISH 136_ PIPLP 141_ SAAEL 146_ LVKRE 151_ NNGSN 156_ PCLMT 161_ ECSGT 166_ SQPPP 171_ ASVPT 176_ TAASE 181_ GRMVI 186_ QDIPA 191_ VTSRG 196_ HVENT 201_ PDLVS 206_ DSTYY 211_ SSFYQ 216_ PSLFP 221_ YYNNL 226_ YNCPQ 231_ YSMAL 236_ AADSA 241_ SGEVG 246_ NPLGG 251_ SPVKN 256_ SLRGL 261_ PGPYV 266_ PGQTG 271_ NQWQM 276_ KNMEN 281_ RHAMS 286_ SQYRM 291_ HSYYP 296_ PPSYL 301_ GQSVP 306_ QFFTF 311_ EDAPS 316_ YPEAR 321_ ASVFS 326_ PPSSQ 331_ DSGLV 336_ SLSSS 341_ SPISN 346_ KSTKA 351_ VLECE 356_ PASEP 361_ SSFTV 366_TPVIE
1: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity)