Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)
1_MSAKV 6_ RLKKL 11_ EQLLL 16_ DGPWR 21_ NESAL 26_ SVETL 31_ LDVLV 36_ CLYTE 41_ CSHSA 46_ LRRDK 51_ YVAEF 56_ LEWAK 61_ PFTQL 66_ VKEMQ 71_ LHRED 76_ FEIIK 81_ VIGRG 86_ AFGEV 91_ AVVKM 96_ KNTER 101_ IYAMK 106_ ILNKW 111_ EMLKR 116_ AETAC 121_ FREER 126_ DVLVN 131_ GDCQW 136_ ITALH 141_ YAFQD 146_ ENHLY 151_ LVMDY 156_ YVGGD 161_ LLTLL 166_ SKFED 171_ KLPED 176_ MARFY 181_ IGEMV 186_ LAIDS 191_ IHQLH 196_ YVHRD 201_ IKPDN 206_ VLLDV 211_ NGHIR 216_ LADFG 221_ SCLKM 226_ NDDGT 231_ VQSSV 236_ AVGTP 241_ DYISP 246_ EILQA 251_ MEDGM 256_ GKYGP 261_ ECDWW 266_ SLGVC 271_ MYEML 276_ YGETP 281_ FYAES 286_ LVETY 291_ GKIMN 296_ HEERF 301_ QFPSH 306_ VTDVS 311_ EEAKD 316_ LIQRL 321_ ICSRE 326_ RRLGQ 331_ NGIED 336_ FKKHA 341_ FFEGL 346_ NWENI 351_ RNLEA 356_ PYIPD 361_ VSSPS 366_ DTSNF 371_ DVDDD 376_ VLRNT 381_ EILPP 386_ GSHTG 391_ FSGLH 396_ LPFIG 401_ FTFTT 406_ ESCFS 411_ DRGSL 416_ KSIMQ 421_ SNTLT 426_ KDEDV 431_ QRDLE 436_ HSLQM 441_ EAYER 446_ RIRRL 451_ EQEKL 456_ ELSRK 461_ LQEST 466_ QTVQS 471_ LHGSS 476_ RALSN 481_ SNRDK 486_ EIKKL 491_ NEEIE 496_ RLKNK 501_ IADSN 506_ RLERQ 511_ LEDTV 516_ ALRQE 521_ REDST 526_ QRLRG 531_ LEKQH 536_ RVVRQ 541_ EKEEL 546_ HKQLV 551_ EASER 556_ LKSQA 561_ KELKD 566_ AHQQR 571_ KLALQ 576_ EFSEL 581_ NERMA 586_ ELRAQ 591_ KQKVS 596_ RQLRD 601_ KEEEM 606_ EVATQ 611_ KVDAM 616_ RQEMR 621_ RAEKL 626_ RKELE 631_ AQLDD 636_ AVAEA 641_ SKERK 646_ LREHS 651_ ENFCK 656_ QMESE 661_ LEALK 666_ VKQGG 671_ RGAGA 676_ TLEHQ 681_ QEISK 686_ IKSEL 691_ EKKVL 696_ FYEEE 701_ LVRRE 706_ ASHVL 711_ EVKNV 716_ KKEVH 721_ DSESH 726_ QLALQ 731_ KEILM 736_ LKDKL 741_ EKSKR 746_ ERHNE 751_ MEEAV 756_ GTIKD 761_ KYERE 766_ RAMLF 771_ DENKK 776_ LTAEN 781_ EKLCS 786_ FVDKL 791_ TAQNR 796_ QLEDE 801_ LQDLA 806_ AKKES 811_ VAHWE 816_ AQIAE 821_ IIQWV 826_ SDEKD 831_ ARGYL 836_ QALAS 841_ KMTEE 846_ LEALR 851_ SSSLG 856_ SRTLD 861_ PLWKV 866_ RRSQK 871_ LDMSA 876_ RLELQ 881_ SALEA 886_ EIRAK 891_ QLVQE 896_ ELRKV 901_ KDANL 906_ TLESK 911_ LKDSE 916_ AKNRE 921_ LLEEM 926_ EILKK 931_ KMEEK 936_ FRADT 941_ GLKLP 946_ DFQDS 951_ IFEYF 956_ NTAPL 961_ AHDLT 966_ FRTSS 971_ ASEQE 976_ TQAPK 981_ PEASP 986_ SMSVA 991_ ASEQQ 996_ EDMAR 1001_ PPQRP 1006_ SAVPL 1011_ PTTQA 1016_ LALAG 1021_ PKPKA 1026_ HQFSI 1031_ KSFSS 1036_ PTQCS 1041_ HCTSL 1046_ MVGLI 1051_ RQGYA 1056_ CEVCS 1061_ FACHV 1066_ SCKDG 1071_ APQVC 1076_ PIPPE 1081_ QSKRP 1086_ LGVDV 1091_ QRGIG 1096_ TAYKG 1101_ HVKVP 1106_ KPTGV 1111_ KKGWQ 1116_ RAYAV 1121_ VCDCK 1126_ LFLYD 1131_ LPEGK 1136_ STQPG 1141_ VIASQ 1146_ VLDLR 1151_ DDEFS 1156_ VSSVL 1161_ ASDVI 1166_ HATRR 1171_ DIPCI 1176_ FRVTA 1181_ SLLGA 1186_ PSKTS 1191_ SLLIL 1196_ TENEN 1201_ EKRKW 1206_ VGILE 1211_ GLQSI 1216_ LHKNR 1221_ LRNQV 1226_ VHVPL 1231_ EAYDS 1236_ SLPLI 1241_ KAILT 1246_ AAIVD 1251_ ADRIA 1256_ VGLEE 1261_ GLYVI 1266_ EVTRD 1271_ VIVRA 1276_ ADCKK 1281_ VHQIE 1286_ LAPRE 1291_ KIVIL 1296_ LCGRN 1301_ HHVHL 1306_ YPWSS 1311_ LDGAE 1316_ GSFDI 1321_ KLPET 1326_ KGCQL 1331_ MATAT 1336_ LKRNS 1341_ GTCLF 1346_ VAVKR 1351_ LILCY 1356_ EIQRT 1361_ KPFHR 1366_ KFNEI 1371_ VAPGS 1376_ VQCLA 1381_ VLRDR 1386_ LCVGY 1391_ PSGFC 1396_ LLSIQ 1401_ GDGQP 1406_ LNLVN 1411_ PNDPS 1416_ LAFLS 1421_ QQSFD 1426_ ALCAV 1431_ ELESE 1436_ EYLLC 1441_ FSHMG 1446_ LYVDP 1451_ QGRRA 1456_ RAQEL 1461_ MWPAA 1466_ PVACS 1471_ CSPTH 1476_ VTVYS 1481_ EYGVD 1486_ VFDVR 1491_ TMEWV 1496_ QTIGL 1501_ RRIRP 1506_ LNSEG 1511_ TLNLL 1516_ NCEPP 1521_ RLIYF 1526_ KSKFS 1531_ GAVLN 1536_ VPDTS 1541_ DNSKK 1546_ QMLRT 1551_ RSKRR 1556_ FVFKV 1561_ PEEER 1566_ LQQRR 1571_ EMLRD 1576_ PELRS 1581_ KMISN 1586_ PTNFN 1591_ HVAHM 1596_ GPGDG 1601_ MQVLM 1606_ DLPLS 1611_ AVPPS 1616_ QEERP 1621_ GPAPT 1626_ NLARQ 1631_ PPSRN 1636_ KPYIS 1641_ WPSSG 1646_ GSEPS 1651_ VTVPL 1656_ RSMSD 1661_ PDQDF 1666_ DKEPD 1671_ SDSTK 1676_ HSTPS 1681_ NSSNP 1686_ SGPPS 1691_ PNSPH 1696_ RSQLP 1701_ LEGLE 1706_QPACD
1: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity)