Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16)
1_MGKKR 6_ TKGKT 11_ VPIDD 16_ SSETL 21_ EPVCR 26_ HIRKG 31_ LEQGN 36_ LKKAL 41_ VNVEW 46_ NICQD 51_ CKTDN 56_ KVKDK 61_ AEEET 66_ EEKPS 71_ VWLCL 76_ KCGHQ 81_ GCGRN 86_ SQEQH 91_ ALKHY 96_ LTPRS 101_ EPHCL 106_ VLSLD 111_ NWSVW 116_ CYVCD 121_ NEVQY 126_ CSSNQ 131_ LGQVV 136_ DYVRK 141_ QASIT 146_ TPKPA 151_ EKDNG 156_ NIELE 161_ NKKLE 166_ KESKN 171_ EQERE 176_ KKENM 181_ AKENP 186_ PMNSP 191_ CQITV 196_ KGLSN 201_ LGNTC 206_ FFNAV 211_ MQNLS 216_ QTPVL 221_ RELLK 226_ EVKMS 231_ GTIVK 236_ IEPPD 241_ LALTE 246_ PLEIN 251_ LEPPG 256_ PLTLA 261_ MSQFL 266_ NEMQE 271_ TKKGV 276_ VTPKE 281_ LFSQV 286_ CKKAV 291_ RFKGY 296_ QQQDS 301_ QELLR 306_ YLLDG 311_ MRAEE 316_ HQRVS 321_ KGILK 326_ AFGNS 331_ TEKLD 336_ EELKN 341_ KVKDY 346_ EKKKS 351_ MPSFV 356_ DRIFG 361_ GELTS 366_ MIMCD 371_ QCRTV 376_ SLVHE 381_ SFLDL 386_ SLPVL 391_ DDQSG 396_ KKSVN 401_ DKNLK 406_ KTVED 411_ EDQDS 416_ EEEKD 421_ NDSYI 426_ KERSD 431_ IPSGT 436_ SKHLQ 441_ KKAKK 446_ QAKKQ 451_ AKNQR 456_ RQQKI 461_ QGKVL 466_ HLNDI 471_ CTIDH 476_ PEDSE 481_ YEAEM 486_ SLQGE 491_ VNIKS 496_ NHISQ 501_ EGVMH 506_ KEYCV 511_ NQKDL 516_ NGQAK 521_ MIESV 526_ TDNQK 531_ STEEV 536_ DMKNI 541_ NMDND 546_ LEVLT 551_ SSPTR 556_ NLNGA 561_ YLTEG 566_ SNGEV 571_ DISNG 576_ FKNLN 581_ LNAAL 586_ HPDEI 591_ NIEIL 596_ NDSHT 601_ PGTKV 606_ YEVVN 611_ EDPET 616_ AFCTL 621_ ANREV 626_ FNTDE 631_ CSIQH 636_ CLYQF 641_ TRNEK 646_ LRDAN 651_ KLLCE 656_ VCTRR 661_ QCNGP 666_ KANIK 671_ GERKH 676_ VYTNA 681_ KKQML 686_ ISLAP 691_ PVLTL 696_ HLKRF 701_ QQAGF 706_ NLRKV 711_ NKHIK 716_ FPEIL 721_ DLAPF 726_ CTLKC 731_ KNVAE 736_ ENTRV 741_ LYSLY 746_ GVVEH 751_ SGTMR 756_ SGHYT 761_ AYAKA 766_ RTANS 771_ HLSNL 776_ VLHGD 781_ IPQDF 786_ EMESK 791_ GQWFH 796_ ISDTH 801_ VQAVP 806_ TTKVL 811_ NSQAY 816_LLFYE
1: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability