Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A)
1_MATKA 6_ RVMYD 11_ FAAEP 16_ GNNEL 21_ TVNEG 26_ EIITI 31_ TNPDV 36_ GGGWL 41_ EGRNI 46_ KGERG 51_ LVPTD 56_ YVEIL 61_ PSDGK 66_ DQFSC 71_ GNSVA 76_ DQAFL 81_ DSLSA 86_ STAQA 91_ SSSAA 96_ SNNHQ 101_ VGSGN 106_ DPWSA 111_ WSASK 116_ SGNWE 121_ SSEGW 126_ GAQPE 131_ GAGAQ 136_ RNTNT 141_ PNNWD 146_ TAFGH 151_ PQAYQ 156_ GPATG 161_ DDDDW 166_ DEDWD 171_ GPKSS 176_ SYFKD 181_ SESAD 186_ AGGAQ 191_ RGNSR 196_ ASSSS 201_ MKIPL 206_ NKFPG 211_ FAKPG 216_ TEQYL 221_ LAKQL 226_ AKPKE 231_ KIPII 236_ VGDYG 241_ PMWVY 246_ PTSTF 251_ DCVVA 256_ DPRKG 261_ SKMYG 266_ LKSYI 271_ EYQLT 276_ PTNTN 281_ RSVNH 286_ RYKHF 291_ DWLYE 296_ RLLVK 301_ FGSAI 306_ PIPSL 311_ PDKQV 316_ TGRFE 321_ EEFIK 326_ MRMER 331_ LQAWM 336_ TRMCR 341_ HPVIS 346_ ESEVF 351_ QQFLN 356_ FRDEK 361_ EWKTG 366_ KRKAE 371_ RDELA 376_ GVMIF 381_ STMEP 386_ EAPDL 391_ DLVEI 396_ EQKCE 401_ AVGKF 406_ TKAMD 411_ DGVKE 416_ LLTVG 421_ QEHWK 426_ RCTGP 431_ LPKEY 436_ QKIGK 441_ ALQSL 446_ ATVFS 451_ SSGYQ 456_ GETDL 461_ NDAIT 466_ EAGKT 471_ YEEIA 476_ SLVAE 481_ QPKKD 486_ LHFLM 491_ ECNHE 496_ YKGFL 501_ GCFPD 506_ IIGTH 511_ KGAIE 516_ KVKES 521_ DKLVA 526_ TSKIT 531_ LQDKQ 536_ NMVKR 541_ VSIMS 546_ YALQA 551_ EMNHF 556_ HSNRI 561_ YDYNS 566_ VIRLY 571_ LEQQV 576_ QFYET 581_ IAEKL 586_RQALS
1: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate