Sorting nexin-5
1_MAAVP 6_ ELLQQ 11_ QEEDR 16_ SKLRS 21_ VSVDL 26_ NVDPS 31_ LQIDI 36_ PDALS 41_ ERDKV 46_ KFTVH 51_ TKTTL 56_ PTFQS 61_ PEFSV 66_ TRQHE 71_ DFVWL 76_ HDTLI 81_ ETTDY 86_ AGLII 91_ PPAPT 96_ KPDFD 101_ GPREK 106_ MQKLG 111_ EGEGS 116_ MTKEE 121_ FAKMK 126_ QELEA 131_ EYLAV 136_ FKKTV 141_ SSHEV 146_ FLQRL 151_ SSHPV 156_ LSKDR 161_ NFHVF 166_ LEYDQ 171_ DLSVR 176_ RKNTK 181_ EMFGG 186_ FFKSV 191_ VKSAD 196_ EVLFT 201_ GVKEV 206_ DDFFE 211_ QEKNF 216_ LINYY 221_ NRIKD 226_ SCVKA 231_ DKMTR 236_ SHKNV 241_ ADDYI 246_ HTAAC 251_ LHSLA 256_ LEEPT 261_ VIKKY 266_ LLKVA 271_ ELFEK 276_ LRKVE 281_ GRVSS 286_ DEDLK 291_ LTELL 296_ RYYML 301_ NIEAA 306_ KDLLY 311_ RRTKA 316_ LIDYE 321_ NSNKA 326_ LDKAR 331_ LKSKD 336_ VKLAE 341_ AHQQE 346_ CCQKF 351_ EQLSE 356_ SAKEE 361_ LINFK 366_ RKRVA 371_ AFRKN 376_ LIEMS 381_ ELEIK 386_ HARNN 391_ VSLLQ 396_SCIDL
1: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941)