Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) (Phospholipase A1) (EC 3.1.1.32)
1_MSNSV 6_ PLLCF 11_ WSLCY 16_ CFAAG 21_ SPVPF 26_ GPEGR 31_ LEDKL 36_ HKPKA 41_ TQTEV 46_ KPSVR 51_ FNLRT 56_ SKDPE 61_ HEGCY 66_ LSVGH 71_ SQPLE 76_ DCSFN 81_ MTAKT 86_ FFIIH 91_ GWTMS 96_ GIFEN 101_ WLHKL 106_ VSALH 111_ TREKD 116_ ANVVV 121_ VDWLP 126_ LAHQL 131_ YTDAV 136_ NNTRV 141_ VGHSI 146_ ARMLD 151_ WLQEK 156_ DDFSL 161_ GNVHL 166_ IGYSL 171_ GAHVA 176_ GYAGN 181_ FVKGT 186_ VGRIT 191_ GLDPA 196_ GPMFE 201_ GADIH 206_ KRLSP 211_ DDADF 216_ VDVLH 221_ TYTRS 226_ FGLSI 231_ GIQMP 236_ VGHID 241_ IYPNG 246_ GDFQP 251_ GCGLN 256_ DVLGS 261_ IAYGT 266_ ITEVV 271_ KCEHE 276_ RAVHL 281_ FVDSL 286_ VNQDK 291_ PSFAF 296_ QCTDS 301_ NRFKK 306_ GICLS 311_ CRKNR 316_ CNSIG 321_ YNAKK 326_ MRNKR 331_ NSKMY 336_ LKTRA 341_ GMPFR 346_ VYHYQ 351_ MKIHV 356_ FSYKN 361_ MGEIE 366_ PTFYV 371_ TLYGT 376_ NADSQ 381_ TLPLE 386_ IVERI 391_ EQNAT 396_ NTFLV 401_ YTEED 406_ LGDLL 411_ KIQLT 416_ WEGAS 421_ QSWYN 426_ LWKEF 431_ RSYLS 436_ QPRNP 441_ GRELN 446_ IRRIR 451_ VKSGE 456_ TQRKL 461_ TFCTE 466_ DPENT 471_ SISPG 476_ RELWF 481_ RKCRD 486_ GWRMK 491_NETSP
1: Exerts both phospholipase and triglyceride lipase activities (PubMed:10192396, PubMed:10318835, PubMed:12032167). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (PubMed:12032167). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (PubMed:10192396, PubMed:12032167)