Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (hFLVCR)
1_MARPD 6_ DEEGA 11_ AVAPG 16_ HPLAK 21_ GYLPL 26_ PRGAP 31_ VGKES 36_ VELQN 41_ GPKAG 46_ TFPVN 51_ GAPRD 56_ SLAAA 61_ SGVLG 66_ GPQTP 71_ LAPEE 76_ ETQAR 81_ LLPAG 86_ AGAET 91_ PGAES 96_ SPLPL 101_ TALSP 106_ RRFVV 111_ LLIFS 116_ LYSLV 121_ NAFQW 126_ IQYSI 131_ ISNVF 136_ EGFYG 141_ VTLLH 146_ IDWLS 151_ MVYML 156_ AYVPL 161_ IFPAT 166_ WLLDT 171_ RGLRL 176_ TALLG 181_ SGLNC 186_ LGAWI 191_ KCGSV 196_ QQHLF 201_ WVTML 206_ GQCLC 211_ SVAQV 216_ FILGL 221_ PSRIA 226_ SVWFG 231_ PKEVS 236_ TACAT 241_ AVLGN 246_ QLGTA 251_ VGFLL 256_ PPVLV 261_ PNTQN 266_ DTNLL 271_ ACNIS 276_ TMFYG 281_ TSAVA 286_ TLLFI 291_ LTAIA 296_ FKEKP 301_ RYPPS 306_ QAQAA 311_ LQDSP 316_ PEEYS 321_ YKKSI 326_ RNLFK 331_ NIPFV 336_ LLLIT 341_ YGIMT 346_ GAFYS 351_ VSTLL 356_ NQMIL 361_ TYYEG 366_ EEVNA 371_ GRIGL 376_ TLVVA 381_ GMVGS 386_ ILCGL 391_ WLDYT 396_ KTYKQ 401_ TTLIV 406_ YILSF 411_ IGMVI 416_ FTFTL 421_ DLRYI 426_ IIVFV 431_ TGGVL 436_ GFFMT 441_ GYLPL 446_ GFEFA 451_ VEITY 456_ PESEG 461_ TSSGL 466_ LNASA 471_ QIFGI 476_ LFTLA 481_ QGKLT 486_ SDYGP 491_ KAGNI 496_ FLCVW 501_ MFIGI 506_ ILTAL 511_ IKSDL 516_ RRHNI 521_ NIGIT 526_ NVDVK 531_ AIPAD 536_ SPTDQ 541_ EPKTV 546_MLSKQ
1: Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis (PubMed:37100056, PubMed:38693265, PubMed:38778100, PubMed:39306721). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (PubMed:38693265, PubMed:38778100). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (PubMed:38693265, PubMed:38778100). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed:15369674, PubMed:20610401, PubMed:22483575, PubMed:23187127, PubMed:27923065)
2: Uniporter that mediates the transport of extracellular choline and ethanolamine into cells (PubMed:37100056, PubMed:38693265). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (PubMed:38693265). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (PubMed:38693265). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed:15369674, PubMed:20610401, PubMed:22483575, PubMed:23187127, PubMed:27923065). Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity (PubMed:20610401). Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies (PubMed:20610401, PubMed:23187127). Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway (PubMed:20610401). Does not export bilirubin (PubMed:20610401). The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (PubMed:20610401, PubMed:23187127)
3: Heme b transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation
4: (Microbial infection) Confers susceptibility to feline leukemia virus subgroup C (FeLV-C) infection in vitro