Cytosolic Fe-S cluster assembly factor NUBP2 (Nucleotide-binding protein 2) (NBP 2)
1_MEAAA 6_ EPGNL 11_ AGVRH 16_ IILVL 21_ SGKGG 26_ VGKST 31_ ISTEL 36_ ALALR 41_ HAGKK 46_ VGILD 51_ VDLCG 56_ PSIPR 61_ MLGAQ 66_ GRAVH 71_ QCDRG 76_ WAPVF 81_ LDREQ 86_ SISLM 91_ SVGFL 96_ LEKPD 101_ EAVVW 106_ RGPKK 111_ NALIK 116_ QFVSD 121_ VAWGE 126_ LDYLV 131_ VDTPP 136_ GTSDE 141_ HMATI 146_ EALRP 151_ YQPLG 156_ ALVVT 161_ TPQAV 166_ SVGDV 171_ RRELT 176_ FCRKT 181_ GLRVM 186_ GIVEN 191_ MSGFT 196_ CPHCT 201_ ECTSV 206_ FSRGG 211_ GEELA 216_ QLAGV 221_ PFLGS 226_ VPLDP 231_ ALMRT 236_ LEEGH 241_ DFIQE 246_ FPGSP 251_ AFAAL 256_ TSIAQ 261_ KILDA 266_TPACL
1: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure