Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294)
1_MSANA 6_ TLKPL 11_ CPILE 16_ QMSRL 21_ QSHSN 26_ TSIRY 31_ IDHAA 36_ VLLHG 41_ LASLL 46_ GLVEN 51_ GVILF 56_ VVGCR 61_ MRQTV 66_ VTTWV 71_ LHLAL 76_ SDLLA 81_ SASLP 86_ FFTYF 91_ LAVGH 96_ SWELG 101_ TTFCK 106_ LHSSI 111_ FFLNM 116_ FASGF 121_ LLSAI 126_ SLDRC 131_ LQVVR 136_ PVWAQ 141_ NHRTV 146_ AAAHK 151_ VCLVL 156_ WALAV 161_ LNTVP 166_ YFVFR 171_ DTISR 176_ LDGRI 181_ MCYYN 186_ VLLLN 191_ PGPDR 196_ DATCN 201_ SRQVA 206_ LAVSK 211_ FLLAF 216_ LVPLA 221_ IIASS 226_ HAAVS 231_ LRLQH 236_ RGRRR 241_ PGRFV 246_ RLVAA 251_ VVAAF 256_ ALCWG 261_ PYHVF 266_ SLLEA 271_ RAHAN 276_ PGLRP 281_ LVWRG 286_ LPFVT 291_ SLAFF 296_ NSVAN 301_ PVLYV 306_ LTCPD 311_ MLRKL 316_ RRSLR 321_ TVLES 326_ VLVDD 331_ SELGG 336_ AGSSR 341_ RRRTS 346_ STARS 351_ ASPLA 356_ LCSRP 361_ EEPRG 366_ PARLL 371_ GWLLG 376_ SCAAS 381_ PQTGP 386_LNRAL
1: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses