Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein)
1_MGSDR 6_ ARKGG 11_ GGPKD 16_ FGAGL 21_ KYNSR 26_ HEKVN 31_ GLEEG 36_ VEFLP 41_ VNNVK 46_ KVEKH 51_ GPGRW 56_ VVLAA 61_ VLIGL 66_ LLVLL 71_ GIGFL 76_ VWHLQ 81_ YRDVR 86_ VQKVF 91_ NGYMR 96_ ITNEN 101_ FVDAY 106_ ENSNS 111_ TEFVS 116_ LASKV 121_ KDALK 126_ LLYSG 131_ VPFLG 136_ PYHKE 141_ SAVTA 146_ FSEGS 151_ VIAYY 156_ WSEFS 161_ IPQHL 166_ VEEAE 171_ RVMAE 176_ ERVVM 181_ LPPRA 186_ RSLKS 191_ FVVTS 196_ VVAFP 201_ TDSKT 206_ VQRTQ 211_ DNSCS 216_ FGLHA 221_ RGVEL 226_ MRFTT 231_ PGFPD 236_ SPYPA 241_ HARCQ 246_ WALRG 251_ DADSV 256_ LSLTF 261_ RSFDL 266_ ASCDE 271_ RGSDL 276_ VTVYN 281_ TLSPM 286_ EPHAL 291_ VQLCG 296_ TYPPS 301_ YNLTF 306_ HSSQN 311_ VLLIT 316_ LITNT 321_ ERRHP 326_ GFEAT 331_ FFQLP 336_ RMSSC 341_ GGRLR 346_ KAQGT 351_ FNSPY 356_ YPGHY 361_ PPNID 366_ CTWNI 371_ EVPNN 376_ QHVKV 381_ RFKFF 386_ YLLEP 391_ GVPAG 396_ TCPKD 401_ YVEIN 406_ GEKYC 411_ GERSQ 416_ FVVTS 421_ NSNKI 426_ TVRFH 431_ SDQSY 436_ TDTGF 441_ LAEYL 446_ SYDSS 451_ DPCPG 456_ QFTCR 461_ TGRCI 466_ RKELR 471_ CDGWA 476_ DCTDH 481_ SDELN 486_ CSCDA 491_ GHQFT 496_ CKNKF 501_ CKPLF 506_ WVCDS 511_ VNDCG 516_ DNSDE 521_ QGCSC 526_ PAQTF 531_ RCSNG 536_ KCLSK 541_ SQQCN 546_ GKDDC 551_ GDGSD 556_ EASCP 561_ KVNVV 566_ TCTKH 571_ TYRCL 576_ NGLCL 581_ SKGNP 586_ ECDGK 591_ EDCSD 596_ GSDEK 601_ DCDCG 606_ LRSFT 611_ RQARV 616_ VGGTD 621_ ADEGE 626_ WPWQV 631_ SLHAL 636_ GQGHI 641_ CGASL 646_ ISPNW 651_ LVSAA 656_ HCYID 661_ DRGFR 666_ YSDPT 671_ QWTAF 676_ LGLHD 681_ QSQRS 686_ APGVQ 691_ ERRLK 696_ RIISH 701_ PFFND 706_ FTFDY 711_ DIALL 716_ ELEKP 721_ AEYSS 726_ MVRPI 731_ CLPDA 736_ SHVFP 741_ AGKAI 746_ WVTGW 751_ GHTQY 756_ GGTGA 761_ LILQK 766_ GEIRV 771_ INQTT 776_ CENLL 781_ PQQIT 786_ PRMMC 791_ VGFLS 796_ GGVDS 801_ CQGDS 806_ GGPLS 811_ SVEAD 816_ GRIFQ 821_ AGVVS 826_ WGDGC 831_ AQRNK 836_ PGVYT 841_ RLPLF 846_RDWIK
1: Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (PubMed:10373424). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (PubMed:18843291). Proteolytically cleaves and therefore activates TMPRSS13 (PubMed:28710277)