Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid receptor)
1_MARCF 6_ SLVLL 11_ LTSIW 16_ TTRLL 21_ VQGSL 26_ RAEEL 31_ SIQVS 36_ CRIMG 41_ ITLVS 46_ KKANQ 51_ QLNFT 56_ EAKEA 61_ CRLLG 66_ LSLAG 71_ KDQVE 76_ TALKA 81_ SFETC 86_ SYGWV 91_ GDGFV 96_ VISRI 101_ SPNPK 106_ CGKNG 111_ VGVLI 116_ WKVPV 121_ SRQFA 126_ AYCYN 131_ SSDTW 136_ TNSCI 141_ PEIIT 146_ TKDPI 151_ FNTQT 156_ ATQTT 161_ EFIVS 166_ DSTYS 171_ VASPY 176_ STIPA 181_ PTTTP 186_ PAPAS 191_ TSIPR 196_ RKKLI 201_ CVTEV 206_ FMETS 211_ TMSTE 216_ TEPFV 221_ ENKAA 226_ FKNEA 231_ AGFGG 236_ VPTAL 241_ LVLAL 246_ LFFGA 251_ AAGLG 256_ FCYVK 261_ RYVKA 266_ FPFTN 271_ KNQQK 276_ EMIET 281_ KVVKE 286_ EKAND 291_ SNPNE 296_ ESKKT 301_ DKNPE 306_ ESKSP 311_ SKTTV 316_RCLEA
1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10037799). Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (PubMed:26823460)