Beta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase)
1_MGALA 6_ RALLL 11_ PLLAQ 16_ WLLRA 21_ APELA 26_ PAPFT 31_ LPLRV 36_ AAATN 41_ RVVAP 46_ TPGPG 51_ TPAER 56_ HADGL 61_ ALALE 66_ PALAS 71_ PAGAA 76_ NFLAM 81_ VDNLQ 86_ GDSGR 91_ GYYLE 96_ MLIGT 101_ PPQKL 106_ QILVD 111_ TGSSN 116_ FAVAG 121_ TPHSY 126_ IDTYF 131_ DTERS 136_ STYRS 141_ KGFDV 146_ TVKYT 151_ QGSWT 156_ GFVGE 161_ DLVTI 166_ PKGFN 171_ TSFLV 176_ NIATI 181_ FESEN 186_ FFLPG 191_ IKWNG 196_ ILGLA 201_ YATLA 206_ KPSSS 211_ LETFF 216_ DSLVT 221_ QANIP 226_ NVFSM 231_ QMCGA 236_ GLPVA 241_ GSGTN 246_ GGSLV 251_ LGGIE 256_ PSLYK 261_ GDIWY 266_ TPIKE 271_ EWYYQ 276_ IEILK 281_ LEIGG 286_ QSLNL 291_ DCREY 296_ NADKA 301_ IVDSG 306_ TTLLR 311_ LPQKV 316_ FDAVV 321_ EAVAR 326_ ASLIP 331_ EFSDG 336_ FWTGS 341_ QLACW 346_ TNSET 351_ PWSYF 356_ PKISI 361_ YLRDE 366_ NSSRS 371_ FRITI 376_ LPQLY 381_ IQPMM 386_ GAGLN 391_ YECYR 396_ FGISP 401_ STNAL 406_ VIGAT 411_ VMEGF 416_ YVIFD 421_ RAQKR 426_ VGFAA 431_ SPCAE 436_ IAGAA 441_ VSEIS 446_ GPFST 451_ EDVAS 456_ NCVPA 461_ QSLSE 466_ PILWI 471_ VSYAL 476_ MSVCG 481_ AILLV 486_ LIVLL 491_ LLPFR 496_ CQRRP 501_ RDPEV 506_ VNDES 511_SLVRH
1: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 (PubMed:10591213, PubMed:11083922, PubMed:11423558, PubMed:15857888, PubMed:16816112). Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets (PubMed:23754390). Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142)